Dyslipidemia, Hypertension
Conditions
Interventions
Intervention group: 125 individuals receive Brazil nut flour for 3 months (14g/dia). Control Group: 125 individuals receive toasted cassava flour flavored for 3 months (10g/day). Individuals will be a
Dietary supplement
HP3.073.433.101
Sponsors
Hospital Universitário Clementino Fraga Filho
Instituto Nacional de Cardiologia
Eligibility
Age
20 Years to 100 Years
Inclusion criteria
Inclusion criteria: Hypertensive and dyslipidemic patients between 20 and 100 years old.
Exclusion criteria
Exclusion criteria: Individuals with known food allergy or aversion to the Brazil nut;Pregnant women and nursing mothers,Be making use of dietary supplements containing antioxidant vitamins or minerals,Show untreated thyroid diseases and destabilized,Display chronic renal failure or liver disease, Being in substance use steroids,Show rheumatic heart disease or systemic collagen, Age up to 20 years and older than 100 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect an increase of 12% glutathione peroxidase activity, measured by Enzyme-Linked Immunosorbent Assay at the beginning and the end of each treatment step (Brazil nut and placebo) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint is increased microvascular vasodilatory, measured by the laser flowmetry speckle technique, a system coupled to a non-invasive drug micro-iontophoresis which evaluates the real time dependent changes in microvascular flow (acetylcholine) endothelium. This examination will take place at the beginning and end of each stage of treatment. | — |
Countries
Brazil
Contacts
Public ContactGlaucia Maria ;Glorimar Oliveira;Rosa
Hospital Universitário Clementino Fraga Filho;Instituto de Nutrição Josué de Castro
Outcome results
None listed