Chronic Periodontitis, Periodontitis
Conditions
Interventions
Nonsurgical periodontal treatment in association with probiotic Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus casei, Lactobacillus salivarus, Lactobacillus plantarum, Lactobacillus
Procedure/surgery
Dietary supplement
E06.721.189.350
G07.203.300.456.500
D26.660
Sponsors
Faculdade de Odontologia da Universidade Federal do Rio de Janeiro
Instituto de Microbiologia Paulo Góes da Universidade Federal do Rio de Janeiro
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Subjects with eighteen years or more; who have at least fourteen natural teeth, excluding third molars; and advanced chronic periodontitis which is determined as pocket probing depth equal or greater than six mm in three or more periodontal sites and bleeding on probing in twenty percent of the sites examined.
Exclusion criteria
Exclusion criteria: Exclusion criteria are the need for antibiotic prophylaxis; having received antibiotics therapy in the three-month period prior to the study; having received periodontal therapy in the six-month period prior to the study; chronic gastrointestinal diseases or abnormalities of the gastrointestinal tract; metabolic disorders; cardiovascular diseases; immunological disorders; HIV infection; be a smoker or have stopped smoking in less than five years; ongoing orthodontic treatment; have Body Mass Index equal or greater than twenty-five; be pregnant or breastfeeding, if woman.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase in intestinal alpha diversity after nonsurgical periodontal treatment, measured by feces microbiological profile showing 0.6% increase in alpha diversity. Data collected previously to periodontal therapy and 2, 6 and 12 months after finishing periodontal therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase in intestinal alpha diversity after nonsurgical periodontal treatment and probiotic use, measured by feces microbiological profile showing increase in alpha diversity higher than 0.6%.; Difference at mean pocket probing depth between the group that use probiotic and the group that used placebo. Data viewed by mean pocket probing depth in probiotic group being 1 mm lower than placebo group. | — |
Countries
Brazil
Contacts
Public ContactAdriana Miranda de Oliveira
Faculdade de Odontologia da Universidade Federal do Rio de Janeiro
Outcome results
None listed