Use of Different Types of Local Anesthetics in Third Molar Removal Surgery

Evaluation and comparison of different types of local anesthetics in lower third molar surgery: a randomized triple-blind clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-2v92y82

Enrollment

Registered

2026-06-17

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative Pain

Interventions

During the preoperative appointment, data regarding sex, age, general health status, complete blood count, platelet count, international normalized ratio (INR), and fasting blood glucose levels will b

DFL®, Brazil), 4% articaine with epinephrine 1:100,000 (Articaine 100

DFL®, Brazil), or 4% articaine with epinephrine 1:200,000 (Articaine 200

DFL®, Brazil), using two 1.8 mL cartridges of anesthetic solution. A full-thickness triangular flap will be performed, followed by peripheral ostectomy and/or odontosection using a high-speed handpiec

Eligibility

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Healthy individuals (American Society of Anesthesiologists - ASA I); of both sexes; aged between 18 and 35 years; in need of removal of lower third molars; third molars that present, on panoramic radiography, similar patterns of root formation, position and degree of impaction when comparing the right and left sides of each volunteer

Exclusion criteria

Exclusion criteria: Smokers; pregnant or breastfeeding women; users of medications prior to surgery that may interact with the patient's pain (e.g. NSAIDs, corticosteroids, analgesics); wearers of orthodontic bands on mandibular second molars; signs of any preoperative inflammatory or infectious condition; systemic diseases; neurological disorders

Design outcomes

Primary

Measure	Time frame
An improvement in clinical parameters related to pain is expected. Data were collected one hour before the intervention and one week after the intervention	—

Secondary

Measure	Time frame
An improvement is expected in the reduction of rescue medication consumption, considering the time to first intake and the total amount used during the first 7 postoperative days. Hemodynamic parameters will also be evaluated, including heart rate, respiratory rate, oximetry, pulse, and body temperature. In addition, the impact on quality of life will be analyzed using the "Oral Health Impact Profile"-14 (OHIP-14) questionnaire, applied preoperatively, 24 hours, and 7 days after the surgical procedure	—

Measure

Time frame

An improvement is expected in the reduction of rescue medication consumption, considering the time to first intake and the total amount used during the first 7 postoperative days. Hemodynamic parameters will also be evaluated, including heart rate, respiratory rate, oximetry, pulse, and body temperature. In addition, the impact on quality of life will be analyzed using the "Oral Health Impact Profile"-14 (OHIP-14) questionnaire, applied preoperatively, 24 hours, and 7 days after the surgical procedure

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Countries

Contacts

Public ContactEdson Cetira Filho

Centro Universitário Christus - UNICHRISTUS

edson.cetira@hotmail.com+5585997219653

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Jun 29, 2026