Anxiety
Conditions
Interventions
The intervention consists of 10 sessions of direct current electrical stimulation at 2mA (2 mili Ampère), lasting 20 minutes, anodic electrode on the primary motor area (C3 or C4), according to 10/20
E02.331.750
Sponsors
Universidade Federal do Amazonas
Universidade Federal do Amazonas
Eligibility
Age
18 Years to 68 Years
Inclusion criteria
Inclusion criteria: Patients with chronic pain manifested for a minimum period of 12 weeks; in clinical treatment with synthetic DMARDs; who present pain in intensity greater or equal 7 by the visual analogical pain scale (EVA-Dor); Who present anxiety symptoms according to the Beck scale (psychological assessment instrument, BAI, Beck Anxiety Inventory); who present symptoms of depression according to the Beck psychological assessment instrument, BDI, Beck Depression Inventory
Exclusion criteria
Exclusion criteria: Patients who have other autoimmune diseases not related to AR; Who are being treated with biological DMARDs; pregnant women; who have a clinical diagnosis of major depressive disorder (greater than 30 in the evaluation score according to Beck Depression Inventory, BDI); with clinical diagnosis of generalized anxiety disorder (GAD), (greater than 31 in the evaluation score according to Beck Anxiety Inventory, BAI); patients with a history of skin diseases; who use high doses of opioids; with a history of illicit drug use/abuse; with metal implants in the cranial or facial region; that use pacemakers; with a history of seizures or epilepsy; with neurological, cognitive and motor deficits; patients who underwent craniotomy; patients with cancer diagnosis; decompensated disease (ischemic heart disease, kidney and/or liver diseases)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of transcranial direct current stimulation (tDCS) on the motor area on symptoms of anxiety and depression in patients with chronic pain diagnosed with Rheumatoid Arthritis (RA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of transcranial direct current stimulation (tDCS) on interleukins IL-1, IL-6, IL-17 and tumor necrosis factor, TNF-a and its correlation with anxiety and depression levels in patients with Rheumatoid Arthritis (RA), through flow cytometry analysis of these immunological markers found in the blood using the BD Bioscience kit ;Effect of transcranial direct current stimulation (tDCS) on the cardiac autonomic behavior of patients with anxiety and depression diagnosed with RA, through assessmento of heart rate variability;Effect of transcranial direct current stimulation (tDCS) on the quality of life of patients with anxiety and depression diagnosed with Rheumatoid Arthritis (RA), trhough Short form - 36 (SF-36);Acute effect of transcranial direct current stimulation (tDCS) on stress symptoms of patients with RA who present with the comorbidities anxiety and depression by quantifying cortisol that can be detected in human saliva, trhough immunoenzymatic assay with the Salimetrics High Sensitivity Salivary Cortisol EIA kit | — |
Countries
Brazil
Contacts
Public ContactMárcia Maia
Universidade Federal do Amazonas
Outcome results
None listed