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Clinical efficacy of endodontic protocols on reduction of cultivable bacteria and endotoxin in infected root canal in patients who have undergone radiation therapy to the head and neck

Investigation of endodontic microbial condition in irratiated patients with cancer.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2t6zbhf
Enrollment
Unknown
Registered
2021-09-08
Start date
2017-02-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periapical periodontits. Cancer.

Interventions

Twenty two patients who have undergone radiation therapy of at least 50 Gy for malign tumor in the head and neck needing primary endodontic treatment were included in this clinical research. Then, as

Sponsors

universidade estadual paulista
Lead Sponsor
universidade estadual paulista
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients who have undergone radiation therapy of at least 50 Gy for malign tumor in the head and neck needing primary endodontic treatment were included in this clinical research. Only single-rooted teeth with diagnostic of primary endodontic infection that was confirmed by a negative response to cold thermal testing with difluorodichloromethane at -50°C (EndoFrost; Roeko, Langenau, Germany) were selected.

Exclusion criteria

Exclusion criteria: The time from the last radiation session had to be a minimum of 6 months. A further requirement was the non existence of periodontal pockets deeper than 4 mm. Teeth not able to be isolated with rubber dam were excluded. Patients under antibiotic treatment in the last 3 months could not be included in this clinical study.

Design outcomes

Primary

MeasureTime frame
The chemomechanical preparation employing reciprocating system in irradiated teeth complemented by final irrigation protocols with either ultrasonic or syringe and a needle demonstrated efficacy in reducing the endodontic contaminant contents.

Secondary

MeasureTime frame
The use of intracanal medication with Ca(OH)2 should be performed in irradiated patients with infected root canals.

Countries

Brazil

Contacts

Public ContactClaudio Carvalho
claudiotalge@fosjc.unesp.brPhone: (55) 12 3947 9400

Outcome results

None listed

Source: REBEC (via WHO ICTRP)