Diabetes Mellitus
Conditions
Interventions
Group Gel - Scaling and root planing and application of gel with green tea extract (0.5%) and hyaluronic acid (0.05%)
This is a randomized, controlled clinical study with 3 proposals. In proposal 1 (split-mouth model clinical study), 90 participants diagnosed with stage II to IV grade A-C periodontitis will be divide
Group D (n=30): participants with decompensated diabetes
and Group F (n=30): smoking participants). The four quadrants (containing at least 2 non-adjacent interproximal sites with probing depth =5 mm and clinical attachment level =3 mm and bleeding on prob
Group aPDT - Scaling and root planing and irrigation with 1 ml of toluidine blue solution (100 µg/ml) followed by application of low-level laser therapy after 1 min
Group aPDT + Gel - Scaling and root planing followed by application of aPDT and Gel. In proposal 2 (split-mouth model clinical study), 90 participants diagnosed with stage II to IV grade A or B period
Group O: irrigation with 10 ml of ozonized water, Group CLX: Scaling and root planing and irrigation with 10 ml of 0.2% chlorhexidine, and Group B: Scaling
Sponsors
Hospital Odontológico da Universidade Federal de Uberlândia
Faculdade de Odontologia da Universidade Federal de Uberlândia
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: For proposals 1 and 2, participants in the first group must be between 18 and 70 years of age; be diagnosed with periodontitis stages II to IV (moderate to severe), grade A to C; with at least two non-adjacent interproximal sites presenting a probing depth greater than or equal to five millimeters; a clinical attachment level greater than or equal to three millimeters and bleeding on probing in all four quadrants; as well as a minimum of fifteen natural teeth. Participants in the second group must present a diagnosis of uncontrolled type 2 diabetes mellitus, with glycated hemoglobin levels greater than or equal to 7%. Participants in the third group must smoke ten or more cigarettes per day for at least three years. For proposal 3, participants must present maxillary and/or mandibular molars with bilateral grade II furcation involvement, located on the buccal, mesial, or distal surfaces of the maxilla or mandible; or the presence of an intrabony defect; a probing depth greater than or equal to five millimeters and a horizontal probing depth greater than or equal to three millimeters (for furcation lesions) after non-surgical periodontal therapy; intraoral periapical radiographs showing radiolucency between the roots for grade II furcation defects and at least three millimeters of evident bone loss on periapical radiographs for intrabony defects; with no endodontic involvement or with satisfactory endodontic treatment
Exclusion criteria
Exclusion criteria: Medical disorders that required antibiotic prophylaxis or that could influence the response to treatment; having received periodontal treatment in the last 6 months; having used medications that affect periodontal tissues in the last 6 months; smokers or ex-smokers for less than 12 months; pregnancy; extensive prosthetic rehabilitation; undergoing orthodontic treatment; carriers of blood diseases; alcoholism and use of illicit drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvements are expected in periodontal clinical parameters assessed using a millimeter periodontal probe. Data collected before the intervention and after 45 and 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of interproximal bone loss by periapical radiographs (baseline and 90 days);Immunological analyses will be performed before the intervention and after 45 and 90 days by ELISA to assess the protein levels of IL-1, TNF, and TGF-ß.;Assessment of periodontopathogen levels by RT-qPCR (baseline, 45 and 90 days) | — |
Countries
Brazil
Contacts
Public ContactJovânia;Suzane Oliveira;Pigossi
Faculdade de Odontologia da Universidade Federal de Uberlândia;Faculdade de Odontologia da Universidade Federal de Uberlândia
Outcome results
None listed