Intestinal constipation
Conditions
Interventions
The selected individuals will be randomized into the following 08 groups:
- Placebo 1 that will receive maltodextrin in a sachet
- Placebo 2 that will receive maltodextrin in capsule
-Lacto sachet that will receive 4 x 108 CFU of Lactobacillus acidophilus (SD 5221) in sachet
- Lacto capsule that will receive 4 x 108 CFU of Lactobacillus acidophilus (SD 5221) in capsules
- Lacto sachet 2 that will receive 4 x 108 CFU of Lactobacillus acidophilus + 5 g of lactitol (additive that will give a better flavor to the product)
- Flora 5 sachet that will receive a sachet containing a mix of probiotics consisting of 109 CFU of Lactobacillus acidophilus (SD 5221), Lactobacillus casei (Lc-11), Lactococcus lactis (Ll-23), Bifido
- Flora 5 capsule that will receive a capsule containing a mix of probiotics consisting of 109 CFU of Lactobacillus acidophilus (SD 5221), Lactobacillus casei (Lc-11), Lactococcus lactis (Ll-23), Bifi
- Flora 20 that will receive a capsule containing a mix of probiotics consisting of 4 x 109 CFU of Lactobacillus acidophilus (SD 5221), Lactobacillus casei (Lc-11), Lactococcus lactis (Ll-23), Bifidob
Dietary supplement
G07.203.300.456.500
Sponsors
Patrícia Borges Botelho
Cifarma Científica Farmacêutica LTDA
Eligibility
Age
19 Years to 70 Years
Inclusion criteria
Inclusion criteria: Men and women aged 19-70 who have low evacuation frequency (2-4 days \ week) and general abdominal discomfort
Exclusion criteria
Exclusion criteria: Volunteers who have diagnosed diseases in the GIT or complications of surgeries resulting from these diseases; presence of hepatic or renal dysfunction; those who have used antibiotics in the last four weeks. Have used in the last four weeks drugs or vitamins or minerals or herbal foods or supplements to reduce digestive symptoms. Those who consumed food containing probiotics and prebiotics before and during the intervention. Volunteers consuming nutraceutical foods with anti-inflammatory activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| If probiotics improve intestinal transit time, evacuation frequency, stool consistencies, and intestinal microbiota composition by increasing the concentration of SCFA in individuals with intestinal constipation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1- Evaluate which type of vehicle provides the best results: sachet or capsule ;2- If the number of strains present in the product influences the response to probiotics ;3- If dose of strains present in the product influences the response to probiotics | — |
Countries
Brazil
Contacts
Public ContactPatrícia Botelho
Universidade de Brasília
Outcome results
None listed