Diabetes Mellitus
Conditions
Interventions
This is an interventionist, experimental, quantitative and prospective study on the development of a diagnostic kit for salivary testing, with the aim of evaluating active periodontal disease, taking
or diagnosed with Periodontitis Stages 2 or 3 and Grade C aged between 18 and 35 years and having 8 teeth with 5mm PS and 3mm insertion loss, without direct relation to clinically detectable etiologic
Sponsors
Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto
Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Minimum of 14 natural teeth (at least 10 posterior); periodontitis diagnosis; Systemically healthy patients; patients diagnosed with diabetes or rheumatoid artrhitis
Exclusion criteria
Exclusion criteria: Smoking, pregnancy; total edentulism; recent periodontal treatment; recent use of antibiotics; patients who refused to sign the Consent Form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: When comparing total protein levels between the study groups, it is expected that concentrations in groups without periodontal disease will be lower than in groups with periodontitis. It is also expected that there will be a reduction in total protein levels after periodontal treatment in all groups.;Outcome found 1: It was observed that the total protein concentrations in the groups without periodontitis were lower than in the groups with periodontitis, and the groups without systemic involvement had lower concentrations of total protein when compared to the groups with diabetes and rheumatoid arthritis. In addition, it was observed that there was a reduction in total protein concentration values ??(µg/mL) between baseline and 45 days in the periodontitis, Diabetes with periodontal health, Diabetes with periodontitis and Arthritis with periodontitis groups, however, this difference was significant only in the periodontitis group, while there was an increase in total protein concentration in the control and Arthritis with periodontal health groups, but this increase was not statistically significant. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2: After periodontal treatment, it is expected that there will be an improvement in the clinical parameters evaluated in all groups and that this improvement will be detectable in the diagnostic test, proving its effectiveness.;Outcome found 2: It was observed that, in the plaque index, there was a reduction in the percentage of plaque in most groups (control, periodontitis, arthritis with periodontitis, diabetes with periodontal health and diabetes with periodontitis), this improvement being statistically significant only in the control, periodontitis and arthritis with periodontitis, while the arthritis with periodontal health group had worsening, but not significantly. In the bleeding index, it was observed that all groups had improvement in the percentage of marginal bleeding, however, in no group was this difference significant. In the probing depth, there was improvement in the periodontitis, arthritis with periodontitis and arthritis with periodontitis groups, but there was only a significant difference in the periodontitis and arthritis with periodontitis groups, while the control groups, diabetes with periodontitis and diabetes with periodontal health showed worsening, but that was not significant. In bleeding on probing, there was improvement in the control, periodontitis, diabetes with periodontal health, diabetes with periodontitis and arthritis with periodontitis groups, but this change was statistically significant only in the periodontitis group, while there was a worsening in the arthritis with periodontal health group, but without statistical significance. Regarding the salivary test, there was an improvement in the periodontitis, diabetes with periodontitis, arthritis with periodontal health and arthritis with periodontitis groups, while there was a worsening in the control and diabetes with periodontal health groups, however, this difference was not significant. On the other hand, visually, it could be observed that there was a ch | — |
Countries
Brazil
Contacts
Public ContactNathalya Moura
Universidade de São Paulo, Faculdade de Odontologia de Ribeirão Preto
Outcome results
None listed