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Evaluation of maternal supplementation with vitamin E in its natural form or synthetic on the levels of alpha-tocopherol in breast milk

Evaluation of maternal supplementation with vitamin E in its natural form (Acetate RRR-alpha-tocopherol) or synthetic (Acetate All-Race-Alpha Tocopherol) on the levels of alpha-tocopherol in breast milk - : MATERNAL SUPPLEMENTATION WITH VITAMIN E

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2przxf
Enrollment
Unknown
Registered
2015-03-27
Start date
2012-01-02
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin E deficiency

Interventions

The present study aimed to assess whether maternal supplementation as well as what kind of alpha-TOH capsule (natural or synthetic), it is more efficient to increase the concentrations of alpha-TOH in
Dietary supplement
SP6.051.227

Sponsors

Universidade Federal do Rio Grande do Norte (Centro Cordenador)
Lead Sponsor
Universidade Federal do Rio Grande do Norte
Collaborator

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Lactating women; normal delivery; term delivery; aged 18 to 40 years.

Exclusion criteria

Exclusion criteria: Women with any clinical sign of disease; infections; syphilis; HIV; gastrointestinal diseases; liver disease; heart disease; diabetes; hypertension; cancer; twin pregnancie; newborn with fetal malformations; history of abortion; use of supplements containing vitamin E during pregnancy

Design outcomes

Primary

MeasureTime frame
Expected outcome: Increased secretion of vitamin E in breast milk after supplementation. This outcome is assessed by determining of alpha- tocopherol concentration in human milk before and after supplementation of supplemented groups and verification of variation percentage, and comparing the test groups concentrations with the control group.;Outcome found: Women who received supplementation showed higher concentrations alpha-tocopherol in colostrum than the control group, with 57% and 39% increase in women supplemented with natural and synthetic forms of vitamin E, respectively.—

Secondary

MeasureTime frame
Expected outcome: Greater increased concentration of vitamin E in breast milk of mothers supplemented with alpha-tocopherol in the natural way, when compared to the synthetic form, verified by determining the concentration of this vitamin in milk before and after supplementation of the supplemented groups and comparison of the variation found percentages, and comparing the concentrations of both groups with the control group.;Outcome found: Women who received the natural vitamin E supplementation had on average 49.6% higher concentration of alpha-tocopherol in milk than those who received synthetic capsules.—

Countries

Brazil

Contacts

Public ContactHeleni Clemente

Universidade Federal do Rio Grande do Norte

heleni.aires22@hotmail.com558432153416

Outcome results

None listed

Source: REBEC (via WHO ICTRP)