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Does a new mechanical ventilation strategy in the immediate postoperative period of cardiac surgery reduce pulmonary complications and is it capable of optimizing the functional capacity of patients at hospital discharge?

Alveolar recruitment with peep titling in the immediate post-operative of cardiac surgery reduces pulmonary complications and is it able to optimize the functional capacity of patients in hospital discharge? A randomized controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2nmwxwt
Enrollment
Unknown
Registered
2021-11-05
Start date
2023-11-30
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac surgical procedures

Interventions

The study will be a randomized controlled clinical trial. Patients aged 18 years or older who undergo elective cardiac surgery with planned use of cardiopulmonary bypass (CPB), aortic clamping and med
E02.041.625.790
E02.365.647.729

Sponsors

Hospital Universitário Pedro Ernesto (HUPE)
Lead Sponsor
Hospital Universitário Pedro Ernesto (HUPE)
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients aged 18 years or over, undergoing elective cardiac surgery for valve replacement (VT) or myocardial revascularization (MVR) or VT with CABG; surgery in the ascending Aortic Artery associated with cardiac surgery; correction of atrial septal defect (ASD); correction of interventricular communication (IVC) with programmed use of cardioplumonary bypass (CPB), clamping of the aorta artery, use of cardioplegia and conventional median sternotomy or median ministernotomy, volume adjusted to an inferior vena cava (IVC) measurement above 18 mm and mean arterial pressure ( MAP) greater than 80 mmHg.

Exclusion criteria

Exclusion criteria: Patients who refuse to participate in the study will be excluded; patients with previous cardiac surgery; pulmonary fibrosis; pulmonary emphysema; pneumonia diagnosed in the last 30 days; patients with pulmonary artery hypertension, with pulmonary artery systolic pressure greater than 45 mmHg; need for orotracheal intubation before arrival in the operating room; obese with body mass index (BMI) greater than 40 kg/m2; need for noradrenaline greater than 2 µg/kg/min; need for re-operation; pneumothorax and/or bubbling drains; patients with neuromuscular disease; myocardial revascularization surgery (CRVM) using a right internal mammary artery (MID) and radial artery graft.

Design outcomes

Primary

MeasureTime frame
It is expected to compare the incidence of postoperative pulmonary complications (PPCs) using the modified Kroenke pulmonary complications score.—

Secondary

MeasureTime frame
It is expected to analyze, in a comparative way, the pulmonary mechanics.;It is also expected to evaluate the implementation of the new mechanical ventilation protocol in the postoperative period of Cardiac Surgery at Hospital Pedro Ernesto (HUPE).;It is expected to analyze, in a comparative way, the performance in the 6-minute walk test (6MWT).;It is expected to analyze, in a comparative way, the length of stay in the intensive care unit (ICU).;It is expected to analyze, in a comparative way, the relationship between the fraction of inspired oxygen (FiO2) and the arterial partial pressure of oxygen (PaO2).—

Countries

Brazil

Contacts

Public ContactNatália Lages

Hospital Universitário Pedro Ernesto (HUPE)

nataliacoronellages@gmail.com+55 (21) 2868-8151

Outcome results

None listed

Source: REBEC (via WHO ICTRP)