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The effect of selenium supplementation through Brazil nut consumption on inflammation, free radicals production and the expression of a protein that have this mineral and of microRNAs in obese women

Effect of selenium supplementation with Brazil nut (Bertholettia excelsa H.B.K.) on inflammation, oxidative stress and selenoprotein P and microRNAs expression in obese women

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2nfy5q
Enrollment
Unknown
Registered
2018-07-13
Start date
2015-08-19
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Experimental group: 36 obese women who will consume 1 unit of Brazil nut per day for 2 months. Control group: 36 obese women who will not receive any type of treatment for 2 months. The participants w
Dietary supplement
SP6.051.227

Sponsors

Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
Lead Sponsor
Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
Collaborator

Eligibility

Sex/Gender
Female
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: BMI from 28.0 to 39.9 kg/m²; do not be pregnant or participating in another clinical trial; do not use vitamin-mineral supplements; do not smoke or drink alcohol chronically; do not practice intense physical activity; do not present food allergy to nuts or report a regular consumption of Brazil nuts.

Exclusion criteria

Exclusion criteria: Present recent infections, high-grade inflammation, chronic cardiovascular and gastrointestinal diseases (inflammatory bowel disease, celiac disease), and cancer

Design outcomes

Primary

MeasureTime frame
Expected outcome 1= Se supplementation through Brazil nut ingestion is able to improve the nutritional status of obese individuals in relation to Se, parameters of inflammation and oxidative stress.;Outcome 1= Significant increase in gene expression (assessed by real-time PCR) of several inflammatory parameters in the supplemented group (IL-6, TNF-?, TLR2 and TLR4) was observed. Regarding microRNAs, only miR-454-3p and miR-584-5p (assessed by real-time PCR) showed a significant increase in the supplemented group after the intervention period. Although there have been no changes in plasma concentrations of inflammatory markers, a significant increase in gene expression may be indicative of a proinflammatory stimulus induced by Brazil nut consumption.—

Secondary

MeasureTime frame
Secondary outcomes are not expected—

Countries

Brazil

Contacts

Public ContactBruna;Graziela Zavarize Reis;Biude Silva

Faculdade de Ciências Farmacêuticas da Universidade de São Paulo;Faculdade de Ciências Farmacêuticas da Universidade de São Paulo

brunazreis@usp.br;gbiude@usp.br+5511953584543;+5511982881473

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 6, 2026