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Angiotensin- (1-7) supplementation in physical exercise practitioners

Angiotensin- (1-7) as a new ergogenic supplement for exercise practitioners

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2nbmpbc
Enrollment
Unknown
Registered
2023-01-06
Start date
2019-03-20
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedentary Behavior

Interventions

The present study was divided into two groups: Group1 (n=20) aerobic capacity and Group2 (n=20) anaerobic capacity. The individuals in both groups will undergo 3 days of physical tests, 7 days apart,

Sponsors

Laboratório de Fisiologia do Exercício
Lead Sponsor
Universidade Federal de Ouro Preto
Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Athletes and practitioners of physical exercise; older than 18 years; involved in their training programs for at least one year; have participated in competition in the last six months at the regional level

Exclusion criteria

Exclusion criteria: Present some type of illness that compromises data collection; individuals with any type of pathology; smokers; make use of medications such as anti-inflammatories and antibiotics and / or others that may compromise research data; as well as supplements that interfere with cardiovascular parameters such as caffeine and guarana

Design outcomes

Primary

MeasureTime frame
Expected Outcome 1: To evaluate the effect of oral formulation of HPß-CD-Angiotensin- (1-7) (3 mg) in mountain bike (MTB) athletes. Expect to find an increase in physical performance through two different protocols: time trial (TT20km) or interval (4 30-second sprints) on a leg cycloergometer. The researchers hypothesize to observe through the protocols: time trial (reduced duration in seconds) or interval (increased power in watts) post intervention with oral supplementation of HPß-CD-Angiotensin- (1-7) (3 mg).;Outcome found 1: For the time trial protocol there was no significant difference between the HPß-CD-Ang-(1-7) condition and the placebo condition in test time (p=0.76). No statistical differences were observed in maximum power between the conditions (HPßCD- placebo = 187.4 ± 21.46 W vs. HPßCD-Ang- (1-7) = 200.4 ± 28.75 W. Mean power was not different between conditions (HPßCD- placebo = 145.2 ± 14.28 W vs. HPßCD-Ang- (1-7) = 157.9 ± 22.19 W. For the variable rotation per minutes (RPM) no difference was observed between conditions (HPßCD- placebo = 95.3 ± 11.51 rpm vs. HPßCD-Ang- (1-7) = 101.4 ± 14.78 rpm. Finally, speed per hour (km/h) showed no differences between conditions (HPßCD- placebo = 25.65 ± 2.88 km/h vs. HPßCD-Ang- (1-7) = 27.9 ± 3.73 km/h. For the repeated sprint protocol for relative maximum power at each stimulus of the test protocol: 1st (7.0 ± 0.6; 7.3 ± 0.7 W), 2nd (6.6 ± 0.8; 6.8 ± 0.8 W), 3rd (6.1 ± 0.8; 6.2 ± 0.7 W) and 4th (5.7 ± 0.8; 5.7 ± 0.9 W) no statistical differences were observed, as well as for relative average power at each stimulus of the test protocol: 1st (5.5 ± 0.6; 5.5 ± 0.7 W), 2nd (5.3 ± 0.7; 5.2 ± 0.5 W), 3rd (4.9 ± 0.4; 4.8 ± 0.6 W) and 4th (4.5 ± 0.8; 4.5 ± 0.6 W); for the fatigue index in each stimulus of the test protocol: 1st (76.5 ± 15.8; 78.5 ± 15.9 %), 2nd (77.4 ± 13.9; 79.3 ± 18.7 %), 3rd (72.0 ± 18.8; 81.0 ± 17.2 %) and 4th (91.6 ± 8.5; 92.0 ± 9.6 %). Furthermore, there was no difference between the mean value

Secondary

MeasureTime frame
Expected outcome 2: To evaluate the effect of oral formulation of HPß-CD-Angiotensin-(1-7) (3 mg) in mountain bike (MTB) athletes. The researchers hypothesize that improved physical performance will not promote changes in cardiovascular parameters (such as: systolic and diastolic blood pressure and heart rate) in the condition treated with oral HPß-CD-Angiotensin-(1-7) (3 mg) supplementation at rest or at peak physical exertion when compared to the placebo group.;Outcome found 1: Supplementation with HPß-CD-Ang-(1-7) did not promote changes in cardiovascular parameters in subjects undergoing the repeated sprints protocol either at rest or at peak exertion. Participants in the time trial protocol showed a reduction in resting diastolic blood pressure values (p=0.025). However, resting SBP and HR did not differ between conditions. Furthermore, at peak exertion no differences were observed between the conditions for SBP, DBP and HR.

Countries

Brazil

Contacts

Public ContactLenice Becker

Universidade Federal de Ouro Preto

lenice@ufop.edu.br+55 031 98897-6327

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 10, 2026