Dementia in Alzheimers disease
Conditions
Interventions
This is a clinical trial with 40 older people with AD in mild and moderate phases, randomized into 20 older people in the Intervention Group (IG) and 20 older people in the Control Group (CG). The IG
Other
G11.427.410.698.277
Sponsors
Universidade Federal de São Carlos
Larissa Pires de Andrade
Eligibility
Age
65 Years to 95 Years
Inclusion criteria
Inclusion criteria: The eligibility criteria used are elderly aged 65 years and over, not institutionalized and with the possibility of contact via telephone or home address. Inclusion criteria are the ability to walk small distances alone without walking aids (minimum 10 meters); willingness to participate in the proposed evaluations and interventions; present a diagnosis of AD in the mild or moderate phases, according to the Manual of Diagnosis and Statistics of Mental Disorders 4th edition (DSM-4) and the Dementia Evaluation Score (CDR) (MORRIS, 1993); and have a medical certificate, suitable for physical exercise. For Biodex analysis, the elderly could not have prosthesis, pacemaker, pain at the time of collection and fracture in the last two years in both lower limbs. For postural control analyzes, the elderly should be able to sit and stand without support
Exclusion criteria
Exclusion criteria: Exclusion criteria are the existence of motor sequelae due to stroke; presence of neurological disorders that interfere with cognition and / or mobility, such as Parkinson's disease, Stroke, Multiple Sclerosis, Huntington's disease, epilepsy and traumatic brain injury; functional or sensory impairments that prevent the application of the proposed tests (limb plegia or paresis, severe tremor and functional impairment of the hands, severe and uncorrected audiovisual disturbance that makes communication difficult during the tests); other types of dementia diagnosed; individuals with advanced AD; any cardiovascular or infectious disease present in the list of absolute contraindications described in the Physical Activity Readiness Medical Examination (2002) (acute infectious disease, dissecting aortic aneurysm, severe aortic stenosis, congestive heart failure, unstable angina, acute myocardial infarction, acute myocarditis, acute pulmonary or systemic embolism, thrombophlebitis, ventricular tachycardia and other dangerous arrhythmias)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcomes are strength, cognition, balance, dual task, functionality, fragility and level of physical activity. Funcionality is the most important outcome. The Intervention Group is expected to show greater funcionality when compared to the Control Group after the intervention;- Cognition: evaluated by Frontal Assessment Battery, Walking Trail Test, Trail Making Test, Addenbooke's Cognitive Examination-Revised. The Intervention Group is expected to have better cognitive function when compared to the Control Group after the intervention;- Balance: evaluated by force platform, Foot Eight Walking, Functional Reach Test, Alternate Step Test, and Calf-raise senior, dual task by force platform concomitant with cognitive and motor tasks The Intervention Group is expected to present a better balance when compared to the Control Group after the intervention;- Dual task: evaluated by force platform concomitant with cognitive and motor tasks. The Intervention Group is expected to have better dual task skills when compared to the Control Group after the intervention;- Functionality: evaluated by Timed Up and Go adapted, Direct Assessment of Functional Status, WHO Disability Assessment Schedule 2.0, Activities of Daily Living Questionnaire, Short Physical Performance Battery, Life-Space assessment, and Environmental Perception Rating Scales The Intervention Group is expected to present better functionality when compared to the Control Group after the intervention;- Fragility: evaluated by FRAIL scale, Edmonton Frail Scale, and five questions chosen by the group. The Intervention Group is expected to present a lower level of frailty when compared to the Control Group after the intervention;- Physical activity level: evaluated by Modified Baecke Questionnaire and triaxial accelerometry using the activPAL3TM system The Intervention Group is expected to show a higher level of physical activity when compared to the Control Group after the intervention;-Depressive sympt | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome consists in the collection of information about adverse clinical events that may occur with the participants during the follow-up period, such as increased use of medications, falls, hospitalizations, institutionalizations, deaths, new diagnoses, need for assistance, changes in routine, participation in social activities, other therapeutic interventions and physical exercise. In addition, qualitative data will also be collected from the participants' caregivers about two perceptions of the intervention protocol. | — |
Countries
Brazil
Contacts
Public ContactNatália Cezar
Universidade Federal de São Carlos
Outcome results
None listed