Moderate depressive episode
Conditions
Interventions
This research consists of a double-blind clinical trial in which we will work with two randomly allocated groups: transcranial magnetic stimulation (TMS) with ACT intervention (experimental group or G
Sponsors
Faculdade de Medicina da Universidade de São Paulo
Faculdade de Medicina da Universidade de São Paulo
Eligibility
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Be over 60 years of age and have an initial Hamilton Scale (HDRS) score greater than 08.
Exclusion criteria
Exclusion criteria: Having other mental disorders (alcohol or drug addiction; psychotic disorders; dementia); presence of severe neurological or clinical diseases; presence of severe suicidal ideation, presence of psychotic symptoms, presence of severe depression characterized as HDRS greater than 28 points, with a CIRS score (Cumulative Illness Rating Scale) > 7, characterizing a set of clinical morbidities that may impair adherence to the protocol of research and presence of (hypo)manic symptoms demonstrated with more than 8 points on the Young Mania Rating Scale and bipolar rapid cyclers. In addition, specific contraindications to the use of rTMS also resulted in exclusion, such as metal implants, epilepsy or electronics in the cephalic segment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measure depressive symptoms using the Hamilton scale (HDRS) at the end of 6 weeks from the beginning of the first day of TBS. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measure depressive symptoms, as well as remission data (decrease of at least 50% of the Hamilton scale - HDRS - initial) and response (HDRS = 7) using the sixth week scales: MADRS (Montgomery-Asberg Depression Rating Scale), GDS (Geriatric Depression Scale), CIRS (Cumulative Illness Rating Scale) and the clinical global impression scale (CGI). | — |
Countries
Brazil
Contacts
Public ContactBruna Teixeira
Faculdade de Medicina da Universidade de São Paulo
Outcome results
None listed