Chronic Chagas disease in indeterminate, cardiac without ventricular dysfunction and cardiac with ventricular dysfunction forms.
Conditions
Interventions
The 60 patients will be evalluated on a specialized clinics for Chagas disease and will undergo laboratory tests, chest X-ray , ECG , stress test, cardiac magnetic resonance imaging, Holter, filling o
Other
Sponsors
Hospital São Rafael
Centro de Biotecnologia e Terapia Celular
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Chagas disease confirmed by 2 different serological tests; optimized drug therapy; NYHA functional class II-III-IV or patients with the indeterminate form; patients of any gender and aged 18 to 70 years.
Exclusion criteria
Exclusion criteria: Valvulopathy with hemodynamic consequences; chronic use of immunosuppressive agents; renal failure on current treatment by dialysis; acute infections or systemic infections in accordance with the definition of sepsis ACCP/SCCM (American College of Chest Phisicians/Society of Critical Care Medicine); abuse alcohol or illicit drugs (Based on DSM IV), any comorbidity with impact on survival in two years; liver, pulmonary, hematologic, neoplastic, bone, inflammatory or infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome: change in the expression profile of microRNAs on the chagasic patients in comparison to healthy patients, verified by PCR, observing a change in 10% in this expression profile. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome: change in the expression profile of microRNAs on patients with cardiac fibrosis in comparison to patients without fibrosis, verified by PCR, observing a change in 10% in this expression profile. | — |
Countries
Brazil
Contacts
Public ContactMilena Soares.
Centro de Biotecnologia e Terapia Celular
Outcome results
None listed