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Effect of chemotherapy on muscle tissue membrane integrity measured by phase angle in women with breast cancer

Effect of chemotherapy on anthropometric indicators, physical activity level, cardiovascular parameters in women with breast cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-2m6qx2r
Enrollment
Unknown
Registered
2023-01-02
Start date
2020-01-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Neoplasms

Interventions

10 breast cancer patients and 11 controls participated in the study. Both groups were evaluated before and after chemotherapy. They were submitted to body composition assessment via bioimpedance analy
E02.319

Sponsors

Universidade Federal do Piauí
Lead Sponsor
Universidade Federal do Piauí
Collaborator

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years, diagnosis of breast cancer, neoadjuvant or adjuvant chemotherapy in their therapeutic protocol.

Exclusion criteria

Exclusion criteria: Participants with a previous diagnosis of chronic obstructive pulmonary disease, heart failure, or infectious diseases were excluded from the study. Additionally, volunteers who did not complete the assessment protocol, were unable to return for reassessment or did not carry out the therapeutic protocol prescribed during chemotherapy were excluded.

Design outcomes

Primary

MeasureTime frame
Expected outcome 1. It is expected to find a deterioration of cell membrane integrity and body composition, assessed through bioimpedance analysis, taking into consideration a decrease of at least 5% in pre- and post-chemotherapy measurements.;Outcome found 1. Chemotherapy had a negative effect on the integrity of the cell membrane of muscle tissue, evidenced by the reduction of PhA, without influence of food intake, lean mass and level of physical activity.

Secondary

MeasureTime frame
No secondary outcomes expected

Countries

Brazil

Contacts

Public ContactValmir Silvino

Universidade Federal do Piauí

valmirsilvino@live.com(+55) 86988524880

Outcome results

None listed

Source: REBEC (via WHO ICTRP)