End Stage Renal Disease
Conditions
Interventions
Hemodialysis with high-performance membrane (Theranova) will be performed on 32 patients with chronic kidney disease 3 times a week for 12 weeks. Endothelial function will be evaluated by brachial art
Procedure/surgery
Sponsors
Fundação Oswaldo Ramos - Hrim
Fundação Oswaldo Ramos - Hrim
Eligibility
Inclusion criteria
Inclusion criteria: Male and female aged 18 years old;in hemodialysis program for at least 6 months before the enrollment; with adequate vascular access; hemodialysis 4 hours 3 times/week; with a result of KtV 1.2 in the 3 months prior to the study and signed the ICF.
Exclusion criteria
Exclusion criteria: Patients with Heart failure III or IV NY class; peripheral arterial disease, previous stroke within the last 3 months before the enrollment; active inflammation or infection disease within the last 3 months before the enrollment; pregnant or lactating female.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expected outcome will be an improvement of endothelial function, defined as an increase of the percentage of flow-mediated dilation evaluated in the brachial artery ultrasound at the end of each phase of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| The expected outcome will be an acute improvement of endothelial function, defined by an increase of the percentage of flow-mediated dilatation assessed by the endopat at the end of the first dialysis session in each phase of the study | — |
Countries
Brazil
Contacts
Public ContactSilvia Manfred
Fundação Oswaldo Ramos - Hrim
Outcome results
None listed