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Comparative evaluation of three different Gingival Grafts

Comparative clinical study between conventional Free Gingival Grafts (EGL) and Inverted Free Gingival Connective Tissue Grafts (EGLCI), in split mouth: study in humans

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2kvnqrm
Enrollment
Unknown
Registered
2023-10-03
Start date
2017-07-19
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival retraction

Interventions

This is a comparative clinical study in split mouth with three arms, one experimental group (inverted connective tissue graft) of 9 volunteers (18 to 60 years) and two control groups (conventional fre

Sponsors

Faculdade de Odontologia de Bauru - Universidade de São Paulo
Lead Sponsor
Faculdade de Odontologia de Bauru - Universidade de São Paulo
Collaborator

Eligibility

Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Healthy patients; both genders; non-smokers; 18 and 60 years old; absence of periodontal disease in the teeth of interest of the research; with indication of increase of the band of keratinized mucosa bilaterally in the region of at least 3 mandibular premolars.

Exclusion criteria

Exclusion criteria: Patients with systemic problems that contraindicate oral surgeries; pregnant women; who were taking or had taken controlled medications and antibiotics in the last 6 months preceding the survey, presence of periodontal disease in the areas of interest of the survey; cognitive impairment; users of illicit drugs or alcohol and smokers; former users of illicit drugs, former smokers and former alcoholics could only be included in the study if they had fully quit their addiction at least 6 months before the start of the survey.

Design outcomes

Primary

MeasureTime frame
Expected outcome 1: It is expected to find aesthetically superior results in sites submitted to connective tissue grafts and inverted free gingival graft compared to sites submitted to conventional connective tissue grafts, and the results will be verified by three experienced periodontists, by the lay opinion of the patients (considering which condition seems more pleasing to them) and also by objective analysis through ImageJ software, comparing with the adjacent vestibular keratinized mucosa.;Outcome found 1: It was observed that the group submitted to conventional free gingival grafts presented statistically different coloration in relation to the other two intervention groups.

Secondary

MeasureTime frame
Expected outcome 2: It is expected to find larger dimensions in the group submitted to conventional free gingival grafts and the results will be evaluated after suturing the grafts (“baseline”), which will be recorded measurements from an “occlusal stent” (measurements A and B), with the aid of a periodontal probe and an endodontic “stop”. ;Outcome found 2: Considering the dimensional analysis of the grafts, it was observed that the conventional and inverted connective tissue grafts contracted significantly in relation to the free gingival grafts, which did not show statistically significant contraction.

Countries

Brazil

Contacts

Public ContactAdriana Sant'Ana

Faculdade de Odontologia de Bauru - Universidade de São Paulo

acpsantana@usp.br+55(14) 32358577

Outcome results

None listed

Source: REBEC (via WHO ICTRP)