Secundary Hypertension, non-specified
Conditions
Interventions
This study is a two-arm, double-blind, randomized controlled clinical trial with parallel groups in which fifty participants will initially undergo two acute experimental sessions, one involving unint
Sponsors
Universidade Federal Rural de Pernambuco
Universidade Federal Rural de Pernambuco
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Presence of high cardiovascular risk and/or a diagnosis of cardiovascular disease, obesity, or diabetes without any signs or symptoms such as chest, neck, jaw, or arm discomfort that may indicate ischemia, shortness of breath at rest or during light exertion, dizziness or syncope, palpitations or tachycardia, known heart murmur, or unusual fatigue or breathlessness during routine activities, whether at rest or during physical effort; and not participating in a physical exercise program for at least three months, combined with occupational activity that involves more than six hours of sitting per day
Exclusion criteria
Exclusion criteria: After study initiation, participants will be excluded only if they demonstrate adherence to less than 85% of the training sessions; engage in another physical exercise program; or change the characteristics of their occupational activities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate flow-mediated dilation (FMD), assessed using two-dimensional ultrasonography with spectral Doppler and a linear transducer following the most recent recommendations, using continuous recordings of the diameter and blood flow of the popliteal artery for 90 seconds under baseline conditions, followed by the application of a cuff positioned above the right ankle inflated to 50 mmHg above systolic blood pressure for five minutes, with recordings resumed 30 seconds before cuff deflation and maintained for an additional 180 seconds after release, considering as the occurrence of the outcome the percentage increase in arterial diameter post-occlusion relative to baseline values, calculated using validated software. An increase in flow-mediated dilation (FMD) is expected in both groups after the intervention, with a statistically significant difference between the control and squat groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate clinical blood pressure, assessed using a validated automatic monitor (HEM-7320, Omron Healthcare, Japan), with measurements obtained after 10 minutes of supine rest using an appropriately sized cuff, performing consecutive readings on the right arm at one-minute intervals until two measurements differ by less than 4 mmHg, considering as the occurrence of the outcome the mean of the last two measurements according to the 7th Brazilian Guideline on Arterial Hypertension; a reduction in blood pressure is expected in both groups after the intervention, with this reduction being more effective and statistically significant in the squat group compared with the control group.;To evaluate 24-hour ambulatory blood pressure, assessed through ambulatory blood pressure monitoring (ABPM) using the Dyna-MAPA device (Cardios, Brazil), properly calibrated and installed with a cuff on the participant’s preferred arm according to the manufacturer’s instructions, programmed to obtain measurements every 15 minutes during the day and every 30 minutes between 23:00 and 7:00, with participants instructed to record any daily or nocturnal events on a specific form, considering as acceptable for analysis only examinations with at least 85% of possible readings over the 24-hour period; the parameters analyzed will include the mean and standard deviation of systolic, diastolic, and mean blood pressure over 24 hours, as well as mean values during wakefulness and sleep, nocturnal dipping calculated as the difference between wakefulness and sleep values, morning surge calculated as the difference between the mean blood pressure in the first hour after waking and the mean blood pressure in the last hour before waking, and blood pressure load defined as the percentage of readings above 140/90 mmHg during wakefulness and/or above 120/80 mmHg during sleep, all analyzed according to the 6th Brazilian ambulatory blood pressure monitoring (ABPM) Guidelines; a reduction in ambulatory blood p | — |
Countries
BR
Contacts
Public ContactAluísio Lima
Universidade Federal Rural de Pernambuco
Outcome results
None listed