Parkinson Disease Other degenerative diseases of nervous system, not elsewhere classified
Conditions
Interventions
This is a randomized controlled clinical trial with three arms and double blinding, including a total of 60 participants allocated into three experimental groups with 20 participants each, consisting
Sponsors
Universidade Anhembi Morumbi
Universidade Anhembi Morumbi
Eligibility
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: Healthy adults and Olympic weightlifting athletes; older adults aged 50 years or older; older adults diagnosed with Parkinson’s disease by a specialist physician in a non-advanced stage and in the ON phase of medication; participants of both sexes
Exclusion criteria
Exclusion criteria: Individuals with orthopedic deformities; other neurological diseases; presence of metal in the head, surgical clips or metallic plates; implanted devices such as pacemakers, deep brain stimulation or cochlear implants; need for assistive devices for locomotion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Observed outcome 1, an improvement in functional mobility was observed in participants submitted to transcranial direct current stimulation combined with physical exercise, verified by means of the Timed Up and Go test, based on a mean reduction of 2.498 seconds in execution time between pre- and post-intervention assessments with statistically significant difference (p < 0.001);Expected outcome 1, it is expected to find an improvement in functional mobility in participants submitted to transcranial direct current stimulation combined with physical exercise, verified by means of the Timed Up and Go test, based on a reduction of at least 2 seconds in execution time between pre- and post-intervention assessments | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2, it is expected to find an improvement in motor control in participants, verified by means of force–tremor coherence analysis, based on a reduction in coherence within the 1 to 4 Hz frequency band between pre- and post-intervention assessments;Observed outcome 2, an improvement in motor control was observed in participants, verified by means of force–tremor coherence analysis, based on a significant reduction in coherence within the 1 to 4 Hz frequency band between pre- and post-intervention assessments (p = 0.0067);Expected outcome 3, it is expected to find an improvement in postural balance in participants, verified by means of anterior–posterior center of pressure displacement analysis, based on an increase in displacement values between pre- and post-intervention assessments;Observed outcome 3, an improvement in postural balance was observed in participants, verified by means of anterior–posterior center of pressure displacement analysis, based on a mean increase of 21.375 mm between pre- and post-intervention assessments with statistically significant difference (p = 0.0269);Expected outcome 4, it is expected to find an association between improvements in functional mobility and motor control in participants, verified by means of correlation analysis between Timed Up and Go performance and force–tremor coherence, based on the identification of a significant correlation between variables;Observed outcome 4, an association between improvements in functional mobility and motor control was observed in participants, verified by means of correlation analysis between Timed Up and Go performance and force–tremor coherence, based on the identification of a significant positive correlation (R = 0.468; p = 0.018) | — |
Countries
BR
Contacts
Public ContactRodrigo Pedreiro
Universidade Anhembi Morumbi
Outcome results
None listed