Multiple sclerosis and Tropical spastic paraparesis in the carrier of T-lymphotropic virus type 1 infection [HTLV-1]
Conditions
Interventions
The clinical history will be assessed and the degree of neurological impairment of the patients will be determined by the Expanded Disability Status Scale (EDSS) Expanded Disability Status Scale Quest
Procedure/surgery
Behavioural
E02.331
I02.233.332
E02.779.483
Sponsors
Universidade Federal de Mato Grosso do Sul
Universidade Federal de Mato Grosso do Sul
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Women with diagnosis defined in Multiple Sclerosis, in the relapsing remitting form And with the disease stabilized for at least four months, EDSS score less than or equal to 6.5. Or women with a diagnosis defined in HAM / TSP, with more than 18 years of age with HTLV - 1 positive ELISA and confirmed by Western blot (HTLV Blot 2.4), with urological and neurological evaluation, Osame Motor Scale dysfunction OMSS) and score in the lower EDSS equal to 6.5. Aged over 18years, cognitive ability to respond to evaluation questionnaires and treatment protocol, presenting symptoms of urinary dysfunction for at least six months (at least three of the following: urgency, Urge incontinence, high voiding frequency, nocturia and nocturnal enuresis), with no history of previous treatment with pelvic floor exercises, those that will not present genital prolapses Or history of previous gynecological surgeries that are not pregnant, with no history of vaginal delivery or cesarean section within a period of less than six months prior to the start of the study, as well as those who will be out of menopause and without urinary infection excluded by laboratory examination.
Exclusion criteria
Exclusion criteria: Pregnant women with Diabetes mellitus, indigenous ethnicity and or quilombola, under the age of 18. Women who present exacerbation of symptoms or outbreak during the course of treatment, those who can not attend the treatment and refuse to perform the proposed treatment or voluntarily give up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A reduction of at least 50% of the urinary symptoms evaluated by the specific questionnaires is expected and an at least 30% increase in the strength and contractility of the pelvic floor evaluated by electromyography and perfect scale, 1 week after the end of intervention in the women treated by electrostimulation and supervised exercises when compared to the control group. ;Improvement of at least 30% in quality of life indices evaluated through the Qualiveen questionnaire 1 week after the end of intervention in the group of women submitted to exercise therapy and electrostimulation of the pelvic floor when compared to the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of at least 30% in sexual function indexes evaluated through the FSFI questionnaire One week after the end of the intervention in the group of women submitted to exercise therapy and electrostimulation of the pelvic floor when compared to the control group.;It expects a benefit in all women involved in the study in view that they will receive conventional medical treatment and health education. | — |
Countries
Brazil
Contacts
Public ContactAna Beatriz Pegorare
Universidade Federal de Mato Grosso do Sul
Outcome results
None listed