Immunosuppression
Conditions
Interventions
Group supplemented with cranberry - CRA (n = 15 subjects): 1 daily dose of cranberry extract (Urell Express Capsules - PAC Standardized cranberry extract - © Newpharma), in capsule, with 36mg proantho
Dietary supplement
SP6.051.227
G11.427.410.698.277
Sponsors
Universidade Federal de Sergipe
Universidade Federal de Sergipe
Eligibility
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Do not have any musculoskeletal, autoimmune, cardiac, pulmonary or hypersensitivity disorders; do not use medications or food supplements including substances with antioxidant function for at least 30 days and antibiotic at least six months prior to the study period; be enrolled in CrossFit Quest and regularly practice for at least three months.
Exclusion criteria
Exclusion criteria: Do not perform any of the blood collections; do not perform any of the physical performance assessments; present any injury or motor impairment to perform the training; any upper respiratory tract infection during the experiment; regularly consume any food supplement composed of vitamins, minerals or bioactive compounds; do not consume any of the cranberry or placebo doses; have known allergy or intolerance to cranberry products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected that the extreme conditioning program of this study will be able to induce transient immunosuppression both after the first session of the second week and in the seventh week. There is also expected to be a greater attenuation in the immunosuppression of the cranberry-supplemented group when compared to placebo after six weeks of training, since supplementation of cranberry for six weeks tends to elevate lymphocyte proliferation, especially. This outcome will be verified using the Attune Flow Cytometer, which will allow the analysis of peripheral blood mononuclear cells. We will observe the function of TCD4+ and TCD8+ cells, expecting superiority in the immume response (between 5 to 10% difference) for the group supplemented with cranberry | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that after six weeks of the extreme conditioning program, the cranberry group will be able to efficiently attenuate the deleterious effects caused by intense physical exercise in oxidative stress, verified through the activity of antioxidant enzymes, and muscle damage , verified by secretion of creatine kinase. It is believed that there will be less oxidative stress and muscle damage (between 5 to 10% difference) in the group supplemented with cranberry. | — |
Countries
Brazil
Contacts
Public ContactAna Mara Silva
Universidade Federal de Sergipe
Outcome results
None listed