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Evaluation of the photodymanic effect of methylene blue dilluted in detergent for the ancillary treatment of periodontal disease

Evaluation of the photodymamic effect mediated by methylene blue in surfactant vehicle for the adjuvant treatment of periodontal disease: randomized, controlled and double-blind clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2g9cf4
Enrollment
Unknown
Registered
2020-07-02
Start date
2020-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

40 patients will be included and all of them will be treated with scaling and root plaining. After 40 days of periodontal treatment, randomization and treatment with antimicrobial photodynamic th
or 2) with antimicrobial photodynamic therapy with methylene blue (n=10)
3) and group treated with scaling and root plaining associated with photosensitizer without light irradiation (n=10), or 4) treated with sodium dodecylsulfate photosensitizer without light irradi
Procedure/surgery
E02.186.500
D02.886.369.517
D02.033.415.220.720
E02.594.540
E02.594

Sponsors

Associação Educacional Nove de Julho
Lead Sponsor
Universidade Nove de Julho
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Have stage III periodontitis, grade B; have at least 10 teeth present with probing depth greater than or equal to 5 mm; clinical attachment level greater than or equal to 5 mm; bleeding index to probing less than 30%; minimum age of 18 years; both genders

Exclusion criteria

Exclusion criteria: Smokers; diabetics; patients with anemia; cancer; pregnant; antibiotic use in the last 6 months; anti-inflammatory use in the last 3 months

Design outcomes

Primary

MeasureTime frame
To evaluate the action of methylene blue in a solution of 0,25% sodium dodecylsulfate in phosphate-buffered saline as an adjunct to the treatment of periodontitis, verifying the amount of colony forming unit of microbiological samples collected before and after the application of antimicrobial photodynamic therapy—

Secondary

MeasureTime frame
To compare the effect of methylene blue in phosphate-buffered saline with methylene blue in a solution of 0,25% sodium dodecylsulfate in phosphate-buffered saline; evaluating the reduction of periodontal pockets through the following periodontal clinical parameters: clinical probing depth, which measures the distance between the gingival margin and the bottom of the pocket; the bleeding on probing index; and the clinical attachment level, which measures the distance between the enamel-cement junction and the bottom of the pocket—

Countries

Brazil

Contacts

Public ContactClaudio Kassa

Universidade Nove de Julho

claudiotkassa@hotmail.com+55-11-33859241

Outcome results

None listed

Source: REBEC (via WHO ICTRP)