Use of a dental mousse to reduce tooth sensitivity after dental bleaching

Effect of the Use of CPP-ACP Mousse in the Management of Post-Bleaching Dental Sensitivity – Randomized, Double-Blind Clinical Study

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

REBEC

Registry ID

RBR-2fyn375

Enrollment

Registered

2026-04-02

Start date

2026-03-02

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth bleaching Dentin Sensitivity

Interventions

This is a randomized controlled double blind split mouth clinical trial to be conducted at the Dental Clinic of Centro Universitário UNIVEL in Cascavel Paraná Brazil. The sample will consist of 30 par

Eligibility

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 30 years; both sexes; presence of all vital anterior teeth; absence of previous dental bleaching; absence of restorations in the anterior region; central incisors with shade A2 or darker according to the Vitapan Classical shade guide; agreement to participate in the study by signing the Informed Consent Form

Exclusion criteria

Exclusion criteria: Absence of anterior teeth; presence of active carious lesions; presence of gingival recession; previous restorative or prosthetic treatment in the anterior region; history of dentin hypersensitivity; tooth discoloration caused by tetracycline use or dental fluorosis; continuous use of anti inflammatory or analgesic medications; pregnancy or breastfeeding

Design outcomes

Primary

Measure	Time frame
To evaluate, through a randomized clinical trial, the effectiveness of CPP-ACP in controlling post-bleaching tooth sensitivity and its influence on color stability after the procedure	—

Secondary

Measure	Time frame
The primary outcome of the study will be tooth sensitivity associated with dental bleaching measured using the Visual Analog Scale during the bleaching procedure every five minutes and at one hour twenty four hours forty eight hours and seven days after treatment comparing the hemiarch treated with casein phosphopeptide amorphous calcium phosphate with the hemiarch treated with a desensitizing agent containing potassium nitrate associated with sodium fluoride. Secondary outcomes will include the evaluation of the degree of dental bleaching and color stability obtained after the procedure assessed before treatment and seven days after bleaching using the Vitapan Classical shade guide with calculation of the variation in shade guide units in order to verify the impact of the application of casein phosphopeptide amorphous calcium phosphate on bleaching effectiveness and stability and to compare its efficacy with potassium nitrate and sodium fluoride in reducing post bleaching tooth sensitivity and promoting remineralizing and desensitizing effects	—

Measure

Time frame

The primary outcome of the study will be tooth sensitivity associated with dental bleaching measured using the Visual Analog Scale during the bleaching procedure every five minutes and at one hour twenty four hours forty eight hours and seven days after treatment comparing the hemiarch treated with casein phosphopeptide amorphous calcium phosphate with the hemiarch treated with a desensitizing agent containing potassium nitrate associated with sodium fluoride. Secondary outcomes will include the evaluation of the degree of dental bleaching and color stability obtained after the procedure assessed before treatment and seven days after bleaching using the Vitapan Classical shade guide with calculation of the variation in shade guide units in order to verify the impact of the application of casein phosphopeptide amorphous calcium phosphate on bleaching effectiveness and stability and to compare its efficacy with potassium nitrate and sodium fluoride in reducing post bleaching tooth sensitivity and promoting remineralizing and desensitizing effects

—

Countries

Contacts

Public ContactLucas de Lima

Centro Universitário Univel

lucasxavierdelima@hotmail.com+55-045-998226068

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: May 1, 2026