immunotherapy
Conditions
Interventions
Follow a group of 27 severe cow's milk protein allergy patients who underwent an oral milk immunotherapy protocol. Follow-up took place during the protocol and one year after the end of the protocol t
V03.175.500
Sponsors
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Eligibility
Age
3 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over three years old; diagnosis of persistent IgE-mediated cows milk allergy with compatible and reproducible immediate symptoms for less than one year or recent positive oral test (one year interval); severe cows milk allergy: as reported or recorded in the medical record of anaphylaxis history; specific IgE for milk, alpha-lactalbumin, beta-lactoglobulin or casein positive by the ImmunoCAP method; positive prick test with a diameter greater than or equal to three millimeters of the negative control for milk in natura; and possess self-injecting adrenaline
Exclusion criteria
Exclusion criteria: Patient diagnosed with cows milk allergy with some degree of tolerance; patient with non-IgE-mediated cows milk allergy; patient with eosinophilic esophagitis prior to immunotherapy; patients with uncontrolled asthma; patients with cardiovascular diseases or other diseases and therapies that contraindicated the use of adrenaline; patients with serious systemic diseases such as autoimmune diseases and malignant neoplasms; and patients and/or caregivers who have difficulty understanding the purpose of treatment, following treatment instructions, and recognizing and treating adverse reactions (not familiar with the action plan)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expected outcome is for the patient to consume milk without reactions and reduction of clinical parameters | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public Contactjuliana de Mendonça
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Outcome results
None listed