dysphagia
Conditions
Interventions
Retrospective stage: 100 patients will have their records reviewed for verification of clinical data and BMI, and analysis of swallowing tests. Prospective stage: 50 patients experimental group will r
Other
Sponsors
Universidade Federal de Santa Catarina
Universidade Federal de Santa Catarina
Eligibility
Age
19 Years to 95 Years
Inclusion criteria
Inclusion criteria: Experimental group with 100 patients with age equal or higher than 19 years; both sexes; without a diagnosis of cancer; without treatment with antibiotics and anti-inflammatory 30 days before collection. Control group healthy volunteers; eutrophic; matched for age and sex with the study group.
Exclusion criteria
Exclusion criteria: Experimental group excluded smokers; patients with fever; diagnosis of edema; cancer; individuals on antibiotics; nonsteroidal anti-inflammatory drugs; immunosuppressants; antihistamines; corticosteroids; chemotherapy; radiotherapy within 30 days before collection of datos.Grupo control excluded patients with pulmonary diseases; cardiovascular; degenerative; neurological; arthritis; cancer; diabetes; smokers; pregnant women and women in the menstrual period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expected to find high inflammatory markers in patients with dysphagia, compared with the control group. The markers evaluated by flow cytometry will myeloperoxidase, TNF-alpha and interleukins (IL1, IL6, IL8, IL10, IL12, TGF beta) .The RCP is checked by nephelometry. Nitric oxide metabolites shall be assessed by reacting Gries | — |
Secondary
| Measure | Time frame |
|---|---|
| We expected to find lower intake of vitamins in patients with dysphagia compared to the control group. Vitamin C is evaluated by colorimetric reaction, vitamina D chemiluminescence, and beta carotene and vitamin E for reading in HPLC. We expected to find a body mass index in patients with dysphagia corresponding malnutrition (below 18.5) and overweight (above 24.99). We expected to find patients with dysphagia with lean mass lower than the control group. It will be obtained by Dual Energy Xray absorptiometry (DEXA). | — |
Countries
Brazil
Contacts
Public ContactEmilia Machado Moreira
Universidade Federal de Santa Catarina
Outcome results
None listed