Skeletal Muscle Enlargement
Conditions
Interventions
The proposed study will be a randomized, single-blind, within-subject, repeated measures trial. The total duration of the study will be 10 weeks. Fourty participants will perform two weekly resistance
resistance training with a 120% increase in volume relative to the previous weekly number of sets [VOL120] – leg 2). The volunteers' legs will be randomized into one of the two experimental conditions
E02.760.169.063.500.387.875
Sponsors
Universidade Federal de São Carlos
Laboratório de Adaptações Neuromusculares ao Treinamento de Força
Eligibility
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Women and men; aged between 18 and 35; who have been practicing strength training for the lower limbs for at least 2 years and no more than 5 years; who perform a weekly volume of 12 to 20 sets for the quadriceps muscles (including the 45º leg press and extension chair exercises).
Exclusion criteria
Exclusion criteria: Use of anabolic steroids; chronic use of vitamin supplements and/or anti-inflammatory medications; any musculoskeletal injury of the lower limbs and neuromuscular disorders that could prevent the execution of the protocols proposed by the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cross-sectional area of the vastus lateralis assessed by ultrasound imaging;Dynamic muscle strength of the lower limbs assessed by one repetition-maximal test | — |
Secondary
| Measure | Time frame |
|---|---|
| Total protein content of ubiquitin-proteasome and calpain pathways through western-blotting;Type I and II muscle fiber cross-sectional area through immunohistochemistry;Single fiber specific tension assessed through immunohistochemistry | — |
Countries
Brazil
Contacts
Public ContactJulio Bueno de Camargo
Universidade Federal de São Carlos
Outcome results
None listed