Burn of unspecified body region, unspecified degree
Conditions
Interventions
This is a two-arm, double-blind, randomized, placebo-controlled clinical trial. The study population will consist of patients aged 18 to 65 years, of both sexes, without exclusion based on ethnicity,
supplemented: placebo), in order of inclusion
Sponsors
Faculdade de Farmácia - Universidade Federal do Rio de Janeiro
Hospital Estadual de Traumatologia e Ortopedia Vereador Melchiades Calazans (HTO Baixada)
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 65 years; both sexs; burned surface area of 10% to 70% (Lund-Browder method, 1944); hospitalized at Centro de Tratamento de Queimados (CTQ) do Hospital de Traumatologia e Ortopedia (HTO); able to eat; able to receive oral supplementation; considered capable of making decisions; understand the research; who accept to participate in the research; able to sign the informed consent form (TCLE); or the person responsible for the patient
Exclusion criteria
Exclusion criteria: Third degree burn; patients who did not continue treatment for more than 7 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluating the effect of supplementation on the time to complete re-epithelialization of the lesions was clinically determined by the presence of a new, stable epithelial layer completely covering the burn, without the need for dressings and without bleeding or ulceration. This observation will be performed by a surgeon from the care team, without knowledge of the treatment of either group, so as not to influence their suggested outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effect of supplementation on length of stay (LOS) compared to placebo;Evaluate the effect of supplementation on death outcomes compared with placebo;Evaluate the effect of supplementation on biochemistry (blood count, liver and kidney function/damage, inflammation, ultrasensitive C-reactive protein CRP) compared with placebo.;Evaluate adverse effects of supplementation compared to placebo | — |
Countries
BR
Contacts
Public ContactLuis Mauricio ;Raphael Lima;Lombardi
Faculdade de Farmácia;Hospital Estadual de Traumatologia e Ortopedia Vereador Melchiades Calazans (HTO Baixada)
Outcome results
None listed