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Early Neuromuscular Electrical Stimulation in Critically Ill Trauma Patients

Neuromuscular electrical stimulation in patients with Traumatic Brain Injury under prolonged mechanical ventilation: a Randomized Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2dbzdy
Enrollment
Unknown
Registered
2016-08-23
Start date
2014-12-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Trauma Intensive Care Units Muscle, Skeletal Electric Stimulation

Interventions

Intervention Group (n=20): In addition to usual care, patients randomized to the NMES group received one daily session of electrical stimulation, in the afternoon, for five consecutive days (weekends
MultiStick®, Axelgaard Manufacturing CO Ltd, Fallbrook, CA, USA) were placed on the motor points of the quadriceps muscles of both legs. The position of the electrodes was remarked daily with an indel
Device
E05.723.402

Sponsors

Universidade de Brasilia - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Lead Sponsor
Hospital de Base do DF
Collaborator
Universidade de Brasilia - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Major trauma patients were assessed for eligibility within the first 24 hours after hospital admission. Adults older than 18 years old with invasive mechanical ventilation were included.

Exclusion criteria

Exclusion criteria: pregnancy; stroke; previous neuromuscular disease; suspicion of brain death; lower limb amputation, fracture or skin lesion that restrained ultrasound evaluation.

Design outcomes

Primary

MeasureTime frame
Expected: Mean change in muscle quality (echogenicity), assessed by muscle ultrasound, based on a minimal variation of 15% in pre and post intervention; mean change in size (thickness), assessed by muscle ultrasound, based on a minimal variation of 8% in pre and post intervention.;Observed: mean change in muscle quality (echogenicity), assessed by muscle ultrasound, of 32% in pre and post intervention; mean change in size (thickness), assessed by muscle ultrasound, based on a minimal variation of 15% in pre and post intervention.—

Secondary

MeasureTime frame
Expected: smaller decrease on circulating levels of IGF-I at intervention group (15%) compared to control group (30%).;Observed: Smaller decrease on circulating levels of IGF-I at intervention group (18%) compared to control group (45%).—

Countries

Brazil

Contacts

Public ContactLuciana Vieira

Universidade de Brasilia - Programa de Pós-Graduação em Ciências e Tecnologias em Saúde

lvto@icloud.com+55 (61) 3376 0252

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 10, 2026