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Antispastic effect of Transcranial Magnetic Stimulation in Multiple Sclerosis

Effects of Transcranial Magnetic Stimulation on spasticity in Multiple Sclerosis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2crspbc
Enrollment
Unknown
Registered
2023-07-11
Start date
2023-02-05
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Spasticity

Interventions

This is a clinical, randomized, crossover and a blind study. Twenty-two individuals diagnosed with Multiple Sclerosis and spasticity in the quadriceps of the right lower limb will participate in each
E02.621.820

Sponsors

Universidade Nove de Julho
Lead Sponsor
Universidade Nove de Julho
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: over 18 years old; left lateral hemispheric dominance; confirmed diagnosis of multiple sclerosis; who present grade 3 spasticity according to the ashworth scale; the subtypes (remitting relapsing, primary progressive and secondary progressive); who have motor evoked potential for quadriceps

Exclusion criteria

Exclusion criteria: Application of phenol; botox or other procedures that interfere with quadriceps muscle tone within a period equal to or less than 6 months; Fracture or recent surgeries in lower limbs; Contracture or ankle deformity; History of seizures or refractory epilepsy; brain metallic implants; brain tumors or skin lesion at the application site

Design outcomes

Primary

MeasureTime frame
It is expected to find a better response for the high frequency protocol, verifying through the ashworth scale and the motor evoked potential the decrease in spasticity at the end of the study.

Secondary

MeasureTime frame
For the secondary outcome, it is expected to find a better motor evoked potential response in individuals with multiple sclerosis after the application of the high frequency protocol with transcranial magnetic stimulation.

Countries

Brazil

Contacts

Public ContactFernanda Correa

Universidade Nove de Julho - Uninove

fecorrea@uni9.pro.br+55(11)26339000

Outcome results

None listed

Source: REBEC (via WHO ICTRP)