Sickle-cell anaemia without crisis
Conditions
Interventions
non-randomized clinical trial in patients with sickle cell disease following
outbreaks and sickle-free for at least 30 days before
inclusion, divided into two groups matched for age and gender: Experi
Control Group: no prescription and supervision of regular exercise.
Experimental Group (EXE) with 14 patients, and Control Group (CON) with 13 patients. Both groups were submitted, before and after th
Other
G11.427.410.698.277
Sponsors
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio de Mesquita Filho
faculdade de Medicina de Botucatu - UNESP
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with sickle cell disease; over 18 year, with no sickle cell crise at least 30 days before the beginning of the exercise protocol; who agreed to participate in the study and signed an informed consent form.
Exclusion criteria
Exclusion criteria: Patients who did not agree to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The analysis of the variables related to the exercise test showed a favorable effect in the group submitted to 8 weeks of regular physical exercise (EXE), showing improvement in the maximum heart rate (maximum HR), in the relative peak VO2, in the distance covered in the exercise test. Regarding ecochordiographic functional capacity, the 8-week home-based exercise program had a favorable impact on left ventricular systolic and diastolic function | — |
Secondary
| Measure | Time frame |
|---|---|
| The home-based exercise program proved to be effective for safety, adherence and viability, as no complications or sickling crisis were observed in the group submitted to exercise (EXE). Regarding the adherence and feasibility of the program, its effectiveness can be observed when observing that all students in the group that exercised concluded the program with an adherence equal to or greater than 3 times a week following the recommendation of the American Thoracic Society. | — |
Countries
Brazil
Contacts
Public ContactJonas;Jonas Araujo Junior;Araujo Junior
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio de Mesquita Filho;Faculdade de Medicina de Botucatu da Universidade Estadual Paulista Júlio de Mesquita Filho
Outcome results
None listed