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Effect of Brazil nut consumption as a source of selenium on the production of free radicals, inflammation and its relationship with a genetic polymorphism of glutathione peroxidase 1 in women with rheumatoid arthritis.

Effect of Brazil nut supplementation (Bertholletia excelsa H.B.K.) as a source of selenium on oxidative stress markers, inflammatory cytokines, and their relationship with Pro198Leu polymorphism in the glutathione peroxidase 1 gene in patients with rheumatoid arthritis.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-289hz3v
Enrollment
Unknown
Registered
2022-06-28
Start date
2011-03-07
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis

Interventions

Experimental group: 30 patients (men and women) diagnosed with rheumatoid arthritis will consume 1 unit of Brazil nuts (approximately 5 grams) per day. Control group: 30 healthy individuals (men and w
G07.203.300.456

Sponsors

Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
Lead Sponsor
Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
Collaborator

Eligibility

Age
20 Years to 59 Years

Inclusion criteria

Inclusion criteria: Patients diagnosed with rheumatoid arthritis (criteria established by the American College of Rheumatology); pharmacological stability of at least 3 months; Healthy individuals with no diagnosis of rheumatologic and autoimmune diseases.

Exclusion criteria

Exclusion criteria: Not pregnant; not be in lactating period; not participating in another clinical trial; not using vitamin-mineral supplements (except calcium and vitamin D); not smoking; not abusing alcohol; not have diagnostic of cancer, thyroid, kidney diseases; not consuming Brazil nuts regularly.

Design outcomes

Primary

MeasureTime frame
Selenium supplementation through Brazil nut ingestion is able to improve the nutritional status of rheumatoid arthritis patients in relation to this mineral, parameters of inflammation, and oxidative stress. Individuals who have the Pro198Leu polymorphism have a reduction in glutathione peroxidase 1 activity.;Patients with rheumatoid arthritis presented a selenium nutritional status deficient, and a scenario of exacerbated oxidative stress and inflammatory response. The supplementation with Brazil nut was efficient to improve selenium status as well as a reduction in oxidative stress. The presence of the Pro198Leu polymorphism modified the responses of selenium biomarkers of CT and TT individuals in relation to supplementation, being lower than that of CC individuals.—

Secondary

MeasureTime frame
Secondary outcomes are not expected—

Countries

Brazil

Contacts

Public ContactSilvia Franciscato Cozzolino

Faculdade de Ciências Farmacêuticas da Universidade de São Paulo

smfcozzo@usp.br+551130913509

Outcome results

None listed

Source: REBEC (via WHO ICTRP)