Hypertension
Conditions
Interventions
This is a prospective, split-mouth clinical study involving the monitoring of crevicular fluid and clinical parameters during the treatment stages, up to six months after the cementation of metal-cera
n = 17) and hypertensive patients using angiotensin-converting enzyme (ACE) inhibitors (e.g., captopril and enalapril
n = 17).
Sponsors
Faculdade de Odontologia de Bauru - Universidade de São Paulo
Faculdade de Odontologia de Bauru - Universidade de São Paulo
Eligibility
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients must not present with any form of periodontitis (e.g., aggressive, chronic, necrotizing); They must be between 30 and 60 years of age; without gender distinction; without race distinction; Participants must present with premolars indicated for restoration with metal-ceramic crowns, regardless of pulpal vitality; The teeth adjacent to those receiving crowns must exhibit the following characteristics: probing depth less than or equal to 3 mm, absence of bleeding on probing and attachment loss, and the presence of contralateral natural premolars; For inclusion in the experimental groups (under treatment with Angiotensin II Type 1 Receptor Blockers or Angiotensin Converting Enzime inhibitors), patients must have been undergoing such treatment for at least six months;
Exclusion criteria
Exclusion criteria: Presence of periodontitis; diagnosis of diabetes mellitus; smoking; pregnancy; lactation; iodine allergy; current orthodontic treatment; use of immunosuppressants; use of anticonvulsants; use of antibiotics; use of anti-inflammatory drugs; use of other classes of antihypertensive medications such as calcium channel blockers and beta-blockers;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: The clinical procedures involved in prosthetic crown rehabilitation are expected to affect the periodontium by altering cytokine expression in the crevicular fluid, and the use of metal-ceramic crowns is also expected to cause local effects when compared to untreated teeth.;Observed outcome 1: The rehabilitative treatment with fixed metal-ceramic single crown led to specific changes in the expression of pro- and anti-inflammatory cytokines in the gingival crevicular fluid, with some markers showing variations in expression depending on the time point.;Expected outcome 2: It is hypothesized that the use of angiotensin II type 1 receptor antagonists (ARBs) or angiotensin-converting enzyme (ACE) inhibitors by patients undergoing oral rehabilitation with single metal-ceramic crowns influences the local production of mediators associated with gingival inflammation in the crevicular fluid.;Observed outcome 2: The blockade of the Renin-Angiotensin System (RAS) was associated with attenuated clinical signs of inflammation and reduced expression of pro-inflammatory markers in the rehabilitated abutment.;Expected outcome 3: The use of angiotensin II type 1 receptor antagonists (ARBs) or angiotensin-converting enzyme (ACE) inhibitors is expected to influence both the quantity and quality of salivary secretion.;Observed outcome 3: There is evidence suggesting that unstimulated salivary flow is reduced in patients using antihypertensive drugs that act on the Renin-Angiotensin System. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected.;No secondary outcomes were noticed. | — |
Countries
Brazil
Contacts
Public ContactIsadora Cano
Faculdade de Odontologia de Bauru - Universidade de São Paulo
Outcome results
None listed