Periodontitis
Conditions
Interventions
This is a randomized, double-blind, split-mouth clinical study. Twenty patients who meet the eligibility criteria will be selected. Both the researchers who will evaluate the outcomes and the particip
D27.505.696.477.396
Sponsors
Faculdade de Odontologia da Universidade Estadual Paulista Julio de Mesquita Filho Campus Araraquara
Centro Universitário Central Paulista
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Healthy volunteers; both genders; over 18 years old; non-smokers; with the presence of stage III grade A periodontitis, in at least two sites in two different quadrants; with a probing depth greater than or equal to five millimeters; active periodontal disease, verified by the presence of bleeding on probing; have at least fifteen remaining teeth
Exclusion criteria
Exclusion criteria: Volunteers with systemic diseases that contraindicate periodontal treatment, which require antibiotic prophylaxis or use of medications that interfere with the evolution of periodontal disease and/or the results of treatment; pregnant or lactating women; volunteers who smoke or who stopped the habit less than 5 years ago; having used antimicrobials in the last three months; having used steroid or non-steroidal anti-inflammatory medications continuously for more than 7 days in the last 3 months; having received periodontal treatment in the last year; have fewer than 15 teeth present
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find a difference in the average Probing Depth (PS) index 30, 90 and 180 days after periodontal treatment. The measurement of the Probing Depth index will be made with a North Carolina periodontal probe (PUNC # 15, Hu-Friedy) in six sites on each tooth , however, the comparative analysis between the groups will be based on the evaluation of the selected sites. The data obtained will be recorded in a standardized clinical form | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to find differences in the microbiological data. The identification of microorganisms present in the subgingival biofilm of the selected sites will be carried out using the Checkerboard DNA-DNA hybridization technique.;It is expected to find variations in the following periodontal clinical indices at the end of six months: Bleeding on probing (SS), clinical attachment level (CIN) and gingival recession (GR). The measurement of the indices will be done with a North Carolina periodontal probe (PUNC # 15, Hu-Friedy) in six sites on each tooth , however, the comparative analysis between the groups will be based on the evaluation of the selected sites.The data obtained will be recorded in a standardized clinical form;It is expected to find variations in the concentration of inflammatory cytokines. Aliquots of each sample of gingival crevicular fluid from the select sites will be examined using the ELISA (Enzyme Immunosorbent Assay) test | — |
Countries
Brazil
Contacts
Public ContactMorgana Guimarães Stabili
Faculdade de Odontologia da Universidade Estadual Paulista Julio de Mesquita Filho Campus Araraquara
Outcome results
None listed