Physical Exertion
Conditions
Interventions
The study will be conducted using a randomized, double-blind, placebo-controlled, counterbalanced crossover design. Approximately 30 healthy, physically active male participants aged 18 to 35 years (c
Citrulline malate administered orally in gelatin capsules at a dose of 8.6 g/day (equivalent to 6 g of citrulline), divided into two doses of 4.3 g, for 7 days, combined with nitrate-depleted beetroot
Corn starch (placebo) administered orally in gelatin capsules for 7 days, combined with acute ingestion of nitrate-rich beetroot juice (12.9 mmol
800 mg nitrate) 2.5 hours prior to testing (active control)
Corn starch (placebo) administered orally in gelatin capsules for 7 days, combined with
Sponsors
Faculdade de Medicina da Universidade de São Paulo
Instituto de Ciências Biomédicas da Universidade de São Paulo
Eligibility
Sex/Gender
Male
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 35 years, healthy, and physically active. To be classified as physically active, participants must complete the International Physical Activity Questionnaire (IPAQ)
Exclusion criteria
Exclusion criteria: Signs, symptoms, or diagnosis of chronic diseases; chronic use of medications such as antihypertensives, corticosteroids, and anti-inflammatory drugs; current or previous use of anabolic androgenic steroids or other substances prohibited in competition (e.g., GH and EPO); use of ergogenic supplements such as creatine and/or beta-alanine within the last 3 months; any medical condition that prevents the performance of cycling ergometer tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to exhaustion (TTE) during a high-intensity constant-load exercise test performed after each supplementation condition | — |
Secondary
| Measure | Time frame |
|---|---|
| VO2 kinetics parameters (e.g., time constant, amplitude, and mean response time) derived from breath-by-breath oxygen uptake data during the exercise test | — |
Countries
BR
Contacts
Public ContactBeatriz da Silva
Faculdade de Medicina da Universidade de São Paulo
Outcome results
None listed