Hypertension
Conditions
Interventions
All of the subjects will be randomly divided in 3 group:
Experimental group 1: Morning training – 20 hypertensives (men and women) will perform 10 week of aerobic training (cycle ergometer, 3x/w, dura
Other
F01.145.632
Sponsors
Escola de Educação Física e Esporte da Universidade de São Paulo
Escola de Educação Física e Esporte da Universidade de São Paulo
Eligibility
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: Men and women; age between 60 and 90 years; hypertensives receiving anti-hypertensive drugs for 4 or more months; neither receiving beta-blockers nor non-dihydropyridine calcium channel blockers; neither chronotype type; inactive or insufficiently active; available to participate in the interventions at both proposed times of day (morning and evening), not taking any hormone replacement.
Exclusion criteria
Exclusion criteria: Presence of cardiovascular diseases beyond hypertension; presence of osteomioarticular problems that unavailable to practice exercise; systolic and diastolic blood pressures higher than 160 and 105 mmHg, respectively; obesity level 2 or above; presence of diabetes with complications or receiving insulin; presence of organ-target damage; presence of complex arrhythmias and/or ischemia during exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of the endothelial function verified by the flow-mediated dilation technique (FMD) with a minimum increase of 4% in artery diameter between the initial and final evaluations;The increase of baroreflex sensitivity calculated by the slope of linear regression generated by the absolute changes in tha HR and muscular nervous sympathetic activity (MNSA) in relation to BP beat-to-beat measured during the Modified Oxford Maneuver, with minimal changes of 0.50 in the slope of HR and 0.60 in the slope of MSNA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decrease of blood pressure measured by auscultatory technique with a minimum reduction of 4 mmHg. ;Improvement of cardiovascular autonomic modulation, as evidenced by the increase of heart rate variability and the reduction of blood pressure measured with the spectral analysis technique.;Reduction of heart rate measured by electrocardiogram with a minimum decrease of 4 bpm between the initial and the final evaluations;Reduction in peripheral vascular resistance based on calculus considering the cardiac output measured by the CO2 rebreathing technique from a minimum 7% reduction between the initial and the final evaluations.;Improvement of endotelial function evaluated by flow-mediated dilation using ultrasonography with a minimal increase of 4% between the initial and the final evaluations.;Decrease of intima-media thickness assessed by duplex ultrasonography with a minimum decrease of 0.04 mm between the initial and final evaluations;Increase of plasma nitric oxide concentration assessed by the chemiluminescence method with a minimum increase of 2 microMol between the initial and final evaluations.;Reduction of plasma C-reactive protein concentration as measured by ELISA with a minimum reduction of 500 pg/ml between the initial and final evaluation;Reduction of oxidative stress assessed by the TBARS Kit with a minimum reduction of 2.7 microMol between the initial and final evaluations | — |
Countries
Brazil
Contacts
Public ContactClaudia Forjaz
Escola de Educação Física e Esporte da Universidade de São Paulo - EEFEUSP
Outcome results
None listed