Other chronic obstructive pulmonary diseases / Chronic Obstructive Pulmonary Disease
Conditions
Interventions
All patients (60) will participate in pulmonary rehabilitation program (PRP), carried out in accordance with the proposal by the American Thoracic Society / Eropean Respiratory Society for six months,
muscular workout located in the lower limbs (major muscle groups related to walking, 2 to 3 sets of 6 to 12 repetitions with workload between 50-85% of 1 maximal repetition) and upper (high number of
Other
G11.427.590.530.698.277
Sponsors
Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA
Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA
Eligibility
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients with moderate to very severe chronic obstructive pulmonary disease; of both genders; presenting clinical stability in the month prior to the beginning of the protocol and aged 40 years or more.
Exclusion criteria
Exclusion criteria: Current smoking; associated diseases that preclude the achievement of some of the evaluations of the study or that limit the progression of training, such as orthopedic, neurological and heart disease; and not signed the free and informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimal improvement of 25 meters on the distance walked on the six-minute walk test. As recommended by the American Thoracic Society (2002), the six-minute walk test will be conducted in a 30-meter flat corridor, demarcated every meter. The individual will be guided to walk as far as possible, with standardized verbal encouragement repeated every minute: (1st minute) "You are doing well"; (2nd minute) "Keep this rhythm"; (3rd minute) "You're doing well, we're halfway through the test", (4th minute) "Keep walking, it's only two minutes"; (5th minute) "Is everything okay? "The test is already at the end." The patient will be allowed to discontinue the test when necessary without interrupting the test.Heart rate, peripheral oxygen saturation, and dyspnea index will be measured at the beginning, every minute and at the end of the test. Blood pressure will be checked only at the beginning and end of the tests, with the individual sitting. There will be two tests, with a rest interval of 30 minutes between them. The predicted values ??will be calculated from the equation proposed by Britto et al (2013). Participants will be tested at the beginning of the protocol, after 24 and 48 sessions. The latter being the moment of discharge. Individuals will be invited to take a new test after 6 and 12 months of discharge. An increase of at least 25 meters in the distance covered in the test will be considered as a parameter of improvement (Holland et al, 2010). | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain derived neurotrophic factor (BDNF) plasmatic levels. For the BDNF assay, plasma will be used, which will be obtained from heparinized blood and centrifuged 10 minutes at 3000 rpm at 4 ° C. The plasma will be stored at a temperature of -80ºC until the day of the analysis. BDNF levels will be measured by the ELISA method using commercial kit (ABCAM®), according to the manufacturer's guidelines. Following the above-mentioned biochemical analyzes, the protein dosage will be performed by the Bradford method73 using bovine albumin as standard. Participants will be submitted to blood sample collection at the beginning of the protocol, after 24 and 48 sessions. The latter being the moment of discharge. Individuals will be invited to make a new collection after 6 and 12 months of discharge. A significance level of 5% will be adopted in the difference between the means of the different moments of assessment.;Reduction of the risk of death, assessed by the BODE Index. The BODE index (Body mass index [B], Obtruction [O], Dyspnea [D], Exercise [E]) is an instrument for assessing the prognosis and risk of mortality in patients with COPD. This instrument associates body mass index (BMI), degree of obstruction to airflow obtained in the spirometric evaluation (forced expiratory volume in the first second), degree of dyspnea obtained by the MRC scale, and exercise capacity assessed by the six-minute walk test. Its score ranges from zero to ten and is divided into quartiles; Where the higher the score, the greater the risk of mortality. Participants will be tested at the beginning of the protocol, after 24 and 48 sessions. The latter being the moment of discharge. Individuals will be invited to take a new test after 6 and 12 months of discharge. A reduction in the risk of death will be considered a reduction in the score of the index accompanied by a change of at least one quartile.;Improvement in memory performance, assessed by the Mini Mental State Examination (MMSE). It | — |
Countries
Brazil
Contacts
Public ContactCintia;Pedro Araujo;Dal Lago
Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA;Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA
Outcome results
None listed