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Benefits of Epidural block in pain control after liver embolization, compared to venous analgesia

Randomized clinical trial on the effectiveness and benefits of Peridural blocking in the control of Post-embolization syndrome, compared to venous analgesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-26gmvg
Enrollment
Unknown
Registered
2018-08-01
Start date
2018-08-20
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Visceral pain

Interventions

Patients will be divided into 2 groups: 1) Venous general anesthesia plus intravenous analgesia with morphine 0.1mg / kg. 2) General venous anesthesia associated with epidural block with 0.5% ropiva
before anesthetic induction
after anesthetic induction
before hepatic arterial embolization
10 minutes after hepatic arterial embolization
after hepatic arterial embolization every 30 minutes until the end of the procedure
and after extubation. All patients will be premedicated in the surgical room with intravenous midazolam 0.05 mg / kg for comfort, and 500 ml crystalloid solution before blocking and induction of anest
Procedure/surgery

Sponsors

Fundação Antônio Prudente
Lead Sponsor
Fundação Antônio Prudente
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients of both genders; 18 years or more; submitted to hepatic embolization; consent to the free and informed consent form.

Exclusion criteria

Exclusion criteria: Absolute contraindications and related to epidural block; patients who remain intubated or are reintubated in the postoperative period; present epidural block failure; with dialysis renal insufficiency or severe hepatic impairment

Design outcomes

Primary

MeasureTime frame
Lower opioid consumption: it is expected that in group 2, submitted to epidural block, patients use less the patient controlled analgesia pump and have lower morphine consumption in the postoperative period up to the time of the acute pain control service. The gauge will be done by the morphine pump itself, which stores in the database the total amount of morphine used in milligrams.

Secondary

MeasureTime frame
Less pain in the postoperative period: patients in group 2 are expected to have a lower pain score in the postoperative period up to hospital discharge. The assessment of the pain score will be done through the verbal numerical scale of 1 to 10, every morning after the surgical procedure, by anesthetist of the pain service. The anesthesiologist will question the patient about the highest pain score he has presented in the last 24 hours. The evaluation will be discontinued and the patient will be discharged from the morphine pump as soon as he has controlled pain, equal to or less than 4.;Incidence of postoperative nausea and vomiting; it is expected that patients in group 2 will have less postoperative nausea and vomiting. Patients will be questioned qualitatively in the post-anesthetic recovery room and every morning postoperatively, whether or not they have had nausea and vomiting. ;Length of hospital stay; it is expected that the patients in group 2 will have shorter hospitalization due to better control of pain.;Rate of ICU admission; it is expected that patients in group 2, submitted to epidural block, will have a lower rate of ICU admission in the postoperative period.

Countries

Brazil

Contacts

Public ContactMichael Quezada

Fundação Antônio Prudente

michael.quezada@gmail.com+55-11-983290565

Outcome results

None listed

Source: REBEC (via WHO ICTRP)