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Effect of cleaning teeth in the levels of c-reactive protein in the blood of patients with severe disease in teeth and bone of the maxilla and mandible

Effect of nonsurgical periodontal therapy on levels of c-reactive protein in serum of subjects with severe periodontitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-24t799
Enrollment
Unknown
Registered
2012-09-28
Start date
2011-06-12
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C-reactive protein, periodontal diseases

Interventions

Nonsurgical periodontal therapy, ie, scaling and root planing of the dental bacterial biofilm and subgingival calculus with specific curettes. Subjects with periodontitis were treated in three stages:
procedure/surgery
E06.721.189.350

Sponsors

Universidade de Brasília
Lead Sponsor
Universidade de Brasília
Collaborator

Eligibility

Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Subjects with periodontitis; Periodontitis group: 19 women, nine men; with at least 18 teeth in upper or lower dental arch; be aged a minimum of 20 and maximum of 45 years; no radiographic evidence of bone loss.

Exclusion criteria

Exclusion criteria: History of smoking; pregnancy or lactation; periodontal therapy; antimicrobial therapy for systemic conditions or use of topical oral antibiotics in the last twelve months; diabetes; autoimmune disease; active acute infections; active severe allergies; active gastrointestinal diseases; active renal diseases; active cancer; morbid obesity (Body mass index -BMI- >40 kg/m2) or underweight (malnourished BMI <18.5 kg/m2); use of medications in the last twelve months that alter the levels of inflammatory mediators.

Design outcomes

Primary

MeasureTime frame
Primary outcomes: after periodontal therapy, it was noted a decrease in all clinical periodontal parameters and levels of C-reactive protein. The reduced levels of high-sensitivity c-reactive protein after periodontal therapy was of sufficient magnitude to provide a positive change in the risk category for cardiovascular disease. The association between improvement of clinical parameters and c-reactive protein levels in patients with severe periodontitis demonstrates the systemic effects of periodontal infection. All clinical periodontal parameters were assessed by clinical examination with a manual millimetric probe. Levels of c-reactive protein were assessed by blood samples.—

Secondary

MeasureTime frame
Secondary outcomes: it was noted a significant increase in high density lipoprotein (HDL) and no significant change in other serum lipids after periodontal therapy.—

Countries

Brazil

Contacts

Public ContactAnne Leite

Universidade de Brasília

annecarolinaleite@gmail.com+55(61)3435-8587

Outcome results

None listed

Source: REBEC (via WHO ICTRP)