Head and Neck Neoplasms
Conditions
Interventions
Assessments in patients before the start of chemotherapy and radiotherapy and during treatments, in 7 moments in the chemotherapy group (7 patients) and 8 moments in the radiotherapy group (10 patient
Device
Sponsors
Universidade de São Paulo - Campus Bauru
Universidade de São Paulo - Campus Bauru
Eligibility
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Diagnosis of malignant tumor; Therapeutic regimen associated with high risk of developing oral mucositis; Standard chemotherapy and or head and neck radiation therapy; Age over 18 years; Control group healthy individuals
Exclusion criteria
Exclusion criteria: Pregnancy; Diabetic; Patients with uncontrolled systemic arterial hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find that changes in blood flow generate a greater incidence of oral mucositis and greater pain intensity in the groups studied through the laser doppler flowmetry method. ;Using the laser doppler flowmetry method, it was observed that there was a change in blood flow in the chemotherapy and radiotherapy group in all evaluations after the start of antineoplastic treatments. In the chemotherapy group, the lowest flow occurred between 7 and 9 days (3rd evaluation) and coincided with the most severe manifestation of oral mucositis on both scales and with the greatest pain intensity. In the radiotherapy group there was also a coincidence between the lowest flow in the 4th week (4th evaluation) with the most severe manifestation of oral mucositis and with the highest pain intensity. Blood flow was similar when compared to the chemotherapy, radiotherapy and control groups; before treatments start. The Kruskal-Wallis statistical test was used to compare blood flow between the chemotherapy, radiotherapy and control groups in the first evaluation, that is, before the start of antineoplastic treatments, the Friedman test was used to compare the first evaluation (moment baseline) with the other assessments throughout the treatments in the study groups and the Spearmann test was applied to assess the correlation of the variables with each other. For all cases, a significance level of 5% was adopted. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public ContactPaulo Santos
Universidade de São Paulo - Campus Bauru
Outcome results
None listed