Sanitation
Conditions
Interventions
This is an observational, cross-sectional, multilevel, and multicenter study with an interdisciplinary profile, to be conducted in the state of Alagoas, Brazil. The study adopts a multilevel approach,
Sponsors
Instituto René Rachou/Fundação Oswaldo Cruz Minas
Fundação Oswaldo Cruz
Eligibility
Age
7 Years to No maximum
Inclusion criteria
Inclusion criteria: Participants of both sexes; older than 7 years of age; participants who reside entirely in the community; community health workers who have been performing the function in the communities included in the study for at least 1 year; municipal coordinators of the Schistosomiasis Control Program
Exclusion criteria
Exclusion criteria: Pregnant or lactating women; individuals with impaired cognitive function or who cannot understand the study; individuals who cannot provide a collected stool sample due to a personal impediment; individuals who have been treated with Praziquantel for less than 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will consist of a dichotomous variable, reflecting: the presence/absence of Schistosoma Mansoni identified by the participants' stool examination; of Biomphalaria sp, identified by integrative taxonomy; the indication of a transmission focus, identified by the presence of mollusks releasing Schistosoma Mansoni cercariae and by the presence/absence of praziquantel resistance markers in treated and untreated participants | — |
Secondary
| Measure | Time frame |
|---|---|
| Will consist of an index to be constructed, combining evidence of disease occurrence based on individual, malacological, and environmental assessments;Presence of praziquantel-resistant Schistosoma mansoni in Brazil and, if confirmed, genomic surveillance of this resistance will be proposed | — |
Countries
Brazil
Contacts
Public ContactRoberta Caldeira
Fundação Oswaldo Cruz
Outcome results
None listed