Obesity
Conditions
Interventions
Women should consume twice a day, three capsules of 500mg after the big meals, totaling six capsules per day (3000mg) of:
- 95% curcuminoid oil
- krill oil (ratio of 900 mg of eicosapentaenoic acid an
Dietary supplement
Sponsors
Flávia Campos Corgosinho
Faculdade de Nutrição - Universidade Federal de Goiás (FANUT-UFG)
Eligibility
Sex/Gender
Female
Age
20 Years to 59 Years
Inclusion criteria
Inclusion criteria: Obese women with BMI above 40kg / m² between 20 and 59 years of age.
Exclusion criteria
Exclusion criteria: Presence of acute inflammatory diseases; infectious diseases; neoplastic diseases; genetic syndromes; present age under 20 years; chronic consumption of vitamin supplements; alcohol (> 30g / day) (SBD, 2017); illicit drugs; do not live in the metropolitan region of goiania; swallowing problems and presenting any kind of intolerance or allergies to food supplement sources.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infiltration of macrophages and morphology of adipocytes in the visceral and subcutaneous adipose tissue: evaluated by immunohistochemistry and the size of the adipocytes will be analyzed as well as the concentration of macrophages by area | — |
Secondary
| Measure | Time frame |
|---|---|
| metabolic profile will be evaluated by performing biochemical tests (fasting glycemia, glycosylated hemoglobin, lipidogram, glutamic-oxalacetic transaminase (GOT), glutamic-pyruvic transaminase (TGP) and C-reactive protein (CRP)) before and after the supplementation of bioactive compounds.;Gene expression of proinflammatory cytokines in subcutaneous and omental adipose tissue: will be evaluated by real-time polymerase chain reaction (qRT-PCR).;Expression of microRNAs related to the translation control of proteins important for inflammation will be evaluated in plasma, omental and subcutaneous adipose tissue samples by real-time polymerase chain reaction (qPCR);Degree of non-alcoholic hepatic steatosis: the liver will be analyzed by ultrasound that will be performed at baseline and post supplementation by an experienced radiologist who will classify steatosis as mild, moderate or severe.;Analysis of the inflammatory profile: interleukins 6 (IL-6), 10 (IL-10), Alpha Tumor Necrosis Factor (TNF-?), Gamma Peroxisome Proliferator Activated Receptor (PPAR-gamma), by enzyme-linked immunosorbent assay | — |
Countries
Brazil
Contacts
Public ContactFlavia Corgosinho
Faculdade de Nutrição - Universidade Federal de Goiás (FANUT-UFG)
Outcome results
None listed