Comparison of the excretion of flavonoids of orange juice by obese and non-obese

Comparative study of the excretion of orange flavonoids, cv. Pera and cv. Moro juices, between lean and obese individuals

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

REBEC

Registry ID

RBR-10xtk662

Enrollment

Unknown

Registered

2021-09-08

Start date

2017-07-12

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy

Interventions

Experiment 1 (Intestinal permeability): Three days before the test, 20 health women and 12 obese women, age between 19 and 40 years, will avoid to intake fruits rich in mannitol, such as apple, guava

23224

56121

56120

Eligibility

Sex/Gender

Female

Age

19 Years to 40 Years

Inclusion criteria

Inclusion criteria: No history of gastrointestinal, hepatic or renal disease;Do not be an alcoholic;Do not be diabetic;Do not be a vegetarian;Do not present any type of infection;Not be making use of vitamin and mineral supplements;Do not be a smoker;Do not practice intense physical activity;They can not be pregnant, breastfeeding or reporting hormone therapy for menopause

Exclusion criteria

Exclusion criteria: Be under 19 and over 40 years old;Do not be female;Have intestinal, kidney or liver disease;Being a vegetarian or a smoker;Practice intense physical activity;Being pregnant or breastfeeding

Design outcomes

Secondary

Measure	Time frame
Secondary outcome: Due to interindividual variability, it was observed that there is a difference in the excretion of flavonoids present in the urine, even in individuals with the same nutritional diagnosis.	—

Primary

Measure	Time frame
Primary outcome: It is expected that lean individuals will be able to excrete more flavonoids in the urine than obese individuals, since the metabolism of flavonoids specific for orange juice is dependent on the intestinal microbiota and that probably obese individuals may present with dysbiosis, hindering the metabolism of these flavonoids.	—

Countries

Brazil

Contacts

Public ContactNeuza Hassimotto

Faculdade de Ciências Farmacêuticas

aymoto@usp.br+55-11-3091-3696

Outcome results

None listed

Source: REBEC (via WHO ICTRP)