Heart Failure, Systolic
Conditions
Interventions
This is a randomized, double-blind, parallel, two-arm clinical trial. Randomization will be performed using a list generated by the randomizer.org statistical website for group composition. Participan
E02.331.750
Sponsors
Universidade Federal do Amazonas
Universidade Federal do Amazonas
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged over 18 years; Both sexes; Ejection fraction (EF) below 40%; Functional class II or III according to NYHA (New York Heart Association); Who are on optimized clinical treatment
Exclusion criteria
Exclusion criteria: Orthopedic dysfunctions that prevent physical exercise (such as, for example, osteoarthritis in the lower limb and/or spine); Neurological and/or cranial alterations that prevent the application of tDCS (Transcranial Direct Current Stimulation); Diagnosed seizures; Unstable angina symptoms; Patients using a pacemaker or implantable ventricular defibrillators; Metabolic syndromes linked to thyroid or liver; Body mass index (BMI) less than 18.5 and greater than 34,9; Patients with less than 3 months of cardiac decompensation; Patients undergoing cardiovascular rehabilitation in the last 12 months; Patients with cognitive disorders, assessed by the Mini Mental State Examination (MMSE) with a lower score in their education category; Uncontrolled diabetes, systemic arterial hypertension and dyslipidemia; Diagnosed lung disease, such as exercise-induced asthma and pulmonary fibrosis; Pregnant women; Smokers; Alcoholics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate functional capacity through the 6-minute walk test by varying the distance covered in meters before and after aerobic training associated with transcranial stimulation with direct current. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess quality of life by applying the Minnesota Living with Heart Failure Questionnaire (MLHFQ), by varying the total score before and after aerobic training associated with transcranial stimulation with direct current.;To evaluate the physical and pulmonary capacity through the cardiopulmonary exercise test using the variables VO2peak mL/Kg/min (oxygen consumption per milliliter/kilogram/minute), minute ventilation slope by carbon dioxide exhalation (VE/V?CO2 slope) and oxygen uptake efficiency slope (OUES) before and after aerobic training associated with transcranial stimulation with direct current. ;To analyze the inflammatory profile using the flow cytometry method, through the quantification of pro-inflammatory cytokines (interleukin-1, interleukin-6 and alpha tumor necrosis factor) and anti-inflammatory cytokines (interleukin-10) before and after aerobic training associated with transcranial stimulation with direct current. | — |
Countries
Brazil
Contacts
Public ContactVanessa Silva
Universidade Federal do Amazonas
Outcome results
None listed