Skeletal Muscle Enlargement Musculoskeletal and Neural Physiological Phenomena
Conditions
Interventions
This is a randomized, controlled, single-blind clinical trial with a within-subject design, in which each participant will perform two distinct resistance training protocols, one in each lower limb. A
Sponsors
Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos
Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos
Eligibility
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Older adult volunteers; both sexes; age between 65 and 80 years; no resistance training for the previous six months; independence in activities of daily living; medical clearance for physical exercise
Exclusion criteria
Exclusion criteria: Diagnosis of decompensated cardiovascular disease or acute infections; diagnosis of neuromuscular disorders, anatomical or functional limitations that preclude participation in resistance training; recent use of corticosteroids or anabolic hormones; recent orthopaedic surgery involving the lower limbs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect that an adaptive resistance training protocol with individualized volume progression (ADAP) will promote greater muscle hypertrophy, assessed by increases in vastus lateralis muscle cross-sectional area [mCSA] measured by B-mode ultrasonography, and lower interindividual variability compared with the traditional resistance training protocol (TRAD) | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the effects of the adaptive resistance training protocol with individualized volume progression (ADAP) and the traditional resistance training protocol (TRAD) on the gene (qPCR) and protein (Western blot) expression of markers of anabolism, catabolism, inflammation, and extracellular matrix remodeling;To compare the effects of the adaptive resistance training protocol with individualized volume progression (ADAP) and the traditional resistance training protocol (TRAD) on satellite cells and myonuclei in type I and type II muscle fibers assessed by immunohistochemistry;To compare the effects of the adaptive resistance training protocol with individualized volume progression (ADAP) and the traditional resistance training protocol (TRAD) on the quantification (relative area/densitometry) and distribution pattern of type I, III, and IV collagens in the extracellular matrix assessed by immunohistochemistry;To compare the effects of the adaptive resistance training protocol with individualized volume progression (ADAP) and the traditional resistance training protocol (TRAD) on the skeletal muscle proteomic profile (pre- vs. post intervention);To compare the effects of the adaptive resistance training protocol with individualized volume progression (ADAP) and the traditional resistance training protocol (TRAD) on muscle strength gains assessed by the one-repetition maximum (1RM) test;To compare the effects of the adaptive resistance training protocol with individualized volume progression (ADAP) and the traditional resistance training protocol (TRAD) on passive stiffness of the vastus lateralis muscle assessed by shear wave elastography using ultrasonography | — |
Countries
BR
Contacts
Public ContactMaíra;Cleiton Scarpelli;Libardi
Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos;Centro de Ciências Biológicas e da Saúde - Universidade Federal de São Carlos
Outcome results
None listed