Lung Diseases
Conditions
Interventions
This prospective cohort study aims to investigate associations between bioelectrical impedance analysis (BIA) phase angle, forced expiratory volume in one second (FEV1), and serum C-reactive protein (
Sponsors
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP
Eligibility
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: Adults of both genders; aged 18 to 59; with Cystic Fibrosis; under the care of a specialized outpatient clinic at a tertiary hospital
Exclusion criteria
Exclusion criteria: Comorbidities characterized by systemic low-grade chronic inflammation or malabsorptive syndromes, except for those secondary to Cystic Fibrosis; malignant neoplasm; edema; chronic kidney disease with glomerular filtration rate less than 60 mg/dL; end-stage organ failure; amputated limbs; gastric or intestinal resections; implanted cardiac devices; chronic use of oral immunosuppressants or anti-inflammatory drugs; initiation of diuretic use or dose modification 3 months prior to recruitment; pulmonary exacerbations within 3 months of recruitment; ethical restrictions that prevent proper consent for study participation; women who are pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find a positive correlation between the phase angle of body bioelectrical impedance analysis and forced expiratory volume in the first second (FEV1) measured by spirometry or plethysmography, with a correlation coefficient greater than or equal to 0.5;It is expected to find an inverse correlation between the phase angle of body bioelectrical impedance analysis and serum levels of C-reactive protein, with a correlation coefficient of less than or equal to -0.5 | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that the phase angle of body bioelectrical impedance analysis will exhibit a correlation coefficient greater than or equal to 0.5 with lean mass and less than or equal to -0.5 with fat mass, both obtained from body bioelectrical impedance analysis | — |
Countries
Brazil
Contacts
Public ContactGustavo Moura
Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo
Outcome results
None listed