Effect of Gum Treatment on saliva and gingival fluid proteins in people with type 2 Diabetes

Effect of Periodontal Treatment on the proteomic profile of saliva and gingival fluid in type 2 diabetic patients with Periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-10vf2byw

Enrollment

Registered

2026-05-09

Start date

2026-06-02

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2 Diabetes Mellitus

Interventions

It is a quasi-experimental interventional clinical study with a 6-month follow-up. Sixty participants will be divided into 3 groups: 20 participants with well-controlled type 2 diabetes mellitus and p

20 participants with poorly controlled type 2 diabetes mellitus and periodontitis

and 20 participants without type 2 diabetes mellitus with periodontitis. Participants with periodontitis will receive non-surgical periodontal treatment, which will consist of supragingival and subgin

Eligibility

Age

31 Years to No maximum

Inclusion criteria

Inclusion criteria: individuals over 30 years of age; with stage III-IV periodontitis; who provide saliva samples of at least 1 ml; who provide complete information on health-related issues; who have at least 15 teeth in their mouth; a minimum of 4 functional teeth and at least 3 adjacent teeth with interproximal papilla in at least one posterior quadrant of the maxilla; and who are able to read, understand, and sign an informed consent form. For participants with diabetes mellitus, the inclusion criterion will be a minimum of 1.5 years since diagnosis

Exclusion criteria

Exclusion criteria: Smokers and former smokers who quit smoking less than 5 years ago, pregnant women, individuals who have undergone periodontal treatment in the last year, undergone antibiotic or anti-inflammatory therapy 3 months prior to inclusion in the study, or who have any other systemic disease, other than type 2 diabetes mellitus, that may alter the course of periodontal disease will be excluded

Design outcomes

Primary

Measure	Time frame
It is expected to identify changes in the proteomic profile of saliva and gingival crevicular fluid following non-surgical periodontal treatment, assessed by proteomic analysis (mass spectrometry), based on the quantitative comparison of protein expression between pre-treatment and 6 months post-treatment time points, considering statistically significant differences (p < 0.05) and/or expression changes greater than 1.5-fold.	—

Measure

Time frame

It is expected to identify changes in the proteomic profile of saliva and gingival crevicular fluid following non-surgical periodontal treatment, assessed by proteomic analysis (mass spectrometry), based on the quantitative comparison of protein expression between pre-treatment and 6 months post-treatment time points, considering statistically significant differences (p < 0.05) and/or expression changes greater than 1.5-fold.

—

Secondary

Measure	Time frame
No secondary outcomes are expected.	—

Countries

Contacts

Public ContactEmanuel Rovai

Universidade Estadual Paulista

emanuel.rovai@unesp.br+55 (12) 3947-9359

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Jun 11, 2026