Essential Hypertension
Conditions
Interventions
The study will involve 45 women with stage 1 hypertension, randomly assigned to three experimental conditions in a crossover design
randomization will be performed by simple draw, and the study will be conducted in a single-blind manner
each volunteer will perform three aerobic exercise sessions spaced at least 48 hours apart: (1) aerobic exercise with blood flow restriction (BFR) adjusted to 50% of arterial occlusion pressure (EABI+
the sessions will last approximately 20 minutes and will be performed on a cycle ergometer at an intensity of 40% of VO2peak
hemodynamic and perceptual responses will be monitored during and after the sessions.
Sponsors
Universidade Federal da Paraíba
Centro de Ciências da Saúde da Universidade Federal da Paraíba
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Be female; be between forty-five and sixty-five years old; have controlled stage one hypertension according to the Brazilian Society of Cardiology classification (2020), with systolic blood pressure between one hundred and forty and one hundred and fifty-nine millimeters of mercury and diastolic blood pressure between ninety and ninety-nine millimeters of mercury, or use continuous antihypertensive medication; have a body mass index lower than thirty-five kilograms per square meter, corresponding at most to class one obesity; have no target organ damage or cardiorespiratory conditions that prevent exercise performance; be a non-smoker; not have diabetes mellitus, with fasting blood glucose lower than one hundred milligrams per deciliter; ankle-brachial index between zero point ninety and one point forty; be physically active according to the International Physical Activity Questionnaire short version; have no cardiopulmonary problems such as unstable angina, acute myocardial infarction, uncontrolled arrhythmia, severe aortic stenosis, decompensated heart failure, acute pulmonary embolism, pulmonary infarction, venous thrombosis, acute myocarditis or pericarditis; not use medications that significantly affect heart rate, such as beta-blockers atenolol, propranolol and metoprolol; not have renal failure with creatinine greater than one point five milligrams per deciliter; voluntarily agree to participate by signing the Informed Consent Form
Exclusion criteria
Exclusion criteria: Participants who present during the experiment any cardiovascular or musculoskeletal aggravation that prevents the continuation of exercise practice; withdraw from the study; show an increase in dosage or change in the class of medication during the observation period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find a significant reduction in systolic, diastolic and mean blood pressure after aerobic exercise sessions with and without blood flow restriction, verified through automatic oscillometric monitoring at rest and at 10, 20, 30, 40, 50 and 60 minutes post-exercise, observing average variations of at least five millimeters of mercury compared to baseline values | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to identify an association between endothelial nitric oxide synthase gene polymorphism and the acute hemodynamic responses to aerobic exercise with and without blood flow restriction, analyzed through peripheral blood genotyping | — |
Countries
Brazil
Contacts
Public ContactWanessa Vasconcelos
Universidade Federal da Paraíba
Outcome results
None listed