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The effect of ozone therapy in the treatment of tooth sensitivity

Clinical performance of Ozone Therapy in the treatment of Dentin Hypersensitivity – Randomized, split-mouth, and a blind clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-10qrnb94
Enrollment
Unknown
Registered
2026-01-14
Start date
2024-08-20
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Sensitivity

Interventions

In this randomized, slipt-mouth and blind studie the patients will be recruited for the study through research dissemination and partnerships, and must follow the inclusion criteria, which include at

Sponsors

Universidade Estadual do Oeste do Paraná
Lead Sponsor
Universidade Estadual do Oeste do Paraná
Collaborator

Eligibility

Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18 to 60 years. Both sexes. Without systemic involvement. Non-smokers. Presence of at least 2 teeth with dentin hypersensitivity on the vestibular surface (at least 1 tooth in each hemiarch)

Exclusion criteria

Exclusion criteria: Dental elements covered by prosthetic work or endodontic treatment. Constant use or with a medical history marked by chronic use of analgesics, anti-inflammatories and psychotropic drugs. Use of orthodontic appliances. Use of desensitizing agents in the last three months. Restorative treatment on the element with sensitivity for less than one month. Abutment teeth of removable partial dentures. Any other painful pathology. Teeth with restorative material on the vestibular surface. Level of cognition that makes it impossible to answer the questionnaires applied. Presence of carious lesions. Pregnant or lactating women. Parafunctional habits. Reflux problems and/or acidic diet. Occlusal problems. Teeth with premature contacts. Teeth with non-carious cervical lesions (clinically noticeable abrasion, abfraction or erosion) and presence of visible sclerotic dentin will be excluded from the research

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of ozone therapy on dentin hypersensitivity, expecting to find a significant reduction in the intensity of pain reported by patients after the intervention. This outcome will be verified through the assessment of dentin sensitivity, using thermal (air blast) and tactile stimuli applied before and after ozone therapy treatment. The occurrence of the outcome will be determined by the statistical comparison of pain scores, measured using the Visual Analog Scale (VAS)

Secondary

MeasureTime frame
To evaluate the duration of the more significant improvement in dentin hypersensitivity compared with the control protocol, expecting to observe a prolonged maintenance of pain reduction in the group submitted to ozone therapy when compared with the control group. This outcome will be verified through longitudinal follow-up of dentin sensitivity, using thermal (air blast) and tactile stimuli applied at different evaluation time points after treatment in both the experimental and control groups. The occurrence of this outcome will be determined by the statistical comparison of pain scores over time, measured using the Visual Analog Scale (VAS)

Countries

Brazil

Contacts

Public ContactJuliana Furlan

Universidade Estadual do Oeste do Paraná

jtomazelifurlan@gmail.com+55 (45) 32203000

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 7, 2026