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Diet and blood Magnesium, Selenium, Folate, Omega-3 and Omega-6 levels in patients with chronic facial pain

Food intake and serum levels of Magnesium, Selenium, Folate, Omega-3 and Omega-6 in patients with Chronic Painful Temporomandibular Dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-10nhhm4v
Enrollment
72
Registered
2026-02-26
Start date
2026-04-05
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporomandibular Joint Dysfunction Syndrome

Interventions

This is an exploratory, observational case-control study to be conducted in the Dentistry program at the Federal University of Ceará. The study is based on the following hypothesis: there are differen
and a TMD Group, composed of women diagnosed with myalgia according to the DC/TMD. To be included, participants in the TMD group must report a pain complaint with no history of prior treatment for at

Sponsors

Departamento de Odontologia Restauradora da Universidade Federal do Ceará Campus Fortaleza
Lead Sponsor
Departamento de Odontologia Restauradora da Universidade Federal do Ceará Campus Fortaleza
Collaborator

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: The volunteers will be female; aged between 20 and 45; seeking treatment at the Dentistry course at the Federal University of Ceará; as well as from the general population, recruited through social media and posters; present painful complaints of at least 5, measured on a Numerical Scale ranging from 0 (no pain) to 10 (worst possible), for at least 3 months and with no history of previous treatment for at least three months; the healthy group will consist of women without Temporomandibular Disorders and with no previous history of facial pain complaints

Exclusion criteria

Exclusion criteria: Women with previously diagnosed disabling cognitive, psychological, and neurological disorders; in addition to a previous diagnosis of chronic kidney disease, liver disease, megaloblastic anemia, or cancer, other chronic painful disorders; abuse of legal drugs and/or alcohol, use of illegal drugs; pregnant and lactating women; volunteers who had lost five or more teeth, poorly fitting dentures, severe periodontal disease, toothache, intraoral or extraoral lesions capable of compromising masticatory function; use of multivitamins or isolated supplements containing magnesium or selenium in the last 30 days; those with systemic conditions likely to cause dietary restrictions, such as lactose intolerance, gluten intolerance, diabetes mellitus, severe irritable bowel syndrome, and inflammatory bowel disease

Design outcomes

Primary

MeasureTime frame
To assess whether there is a difference in serum magnesium and selenium levels in asymptomatic women compared to women with chronic painful TMD, verified by the standardized method of multielement analysis using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) equipment

Secondary

MeasureTime frame
No secondary outcomes are expected

Countries

Brazil

Contacts

Public ContactIgor Ribeiro

Universidade Federal do Ceará

igorferreira0.2.3@gmail.com+55 (85) 992680909

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Mar 14, 2026